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dc.contributor.author | Chaplin, Alice | |
dc.contributor.author | Parra, Pilar | |
dc.contributor.author | Serra, Francisca | |
dc.contributor.author | Palou, Andreu | |
dc.date.accessioned | 2024-07-04T12:54:59Z | |
dc.date.available | 2024-07-04T12:54:59Z | |
dc.date.issued | 2015-04-27 | |
dc.identifier.citation | Chaplin A, Parra P, Serra F, Palou Oliver A. Conjugated Linoleic Acid Supplementation under a High-Fat Diet Modulates Stomach Protein Expression and Intestinal Microbiota in Adult Mice. PLoS One. 2015 Apr 27;10(4):e0125091. | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10876 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20113 | |
dc.description.abstract | The gastrointestinal tract constitutes a physiological interface integrating nutrient and microbiota-host metabolism. Conjugated linoleic acids (CLA) have been reported to contribute to decreased body weight and fat accretion. The modulation by dietary CLA of stomach proteins related to energy homeostasis or microbiota may be involved, although this has not been previously analysed. This is examined in the present study, which aims to underline the potential mechanisms of CLA which contribute to body weight regulation. Adult mice were fed either a normal fat (NF, 12% kJ content as fat) or a high-fat (HF, 43% kJ content as fat) diet. In the latter case, half of the animals received daily oral supplementation of CLA. Expression and content of stomach proteins and specific bacterial populations from caecum were analysed. CLA supplementation was associated with an increase in stomach protein expression, and exerted a prebiotic action on both Bacteroidetes/Prevotella and Akkermansia muciniphila. However, CLA supplementation was not able to override the negative effects of HF diet on Bifidobacterium spp., which was decreased in both HF and HF+CLA groups. Our data show that CLA are able to modulate stomach protein expression and exert a prebiotic effect on specific gut bacterial species. | en |
dc.description.sponsorship | This work was supported by the grant AGL2012-33692 and the EU-funded project (BIOCLAIMS FP7-244995). The authors' group receives financial support from Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion, CIBERobn. Authors belong to the Nutrigenomics-group, awarded as Group of Excellence of CAIB and supported by Direccio General d'Universitats, Recerca i Transferencia del Coneixement of Regional Government (CAIB) and FEDER funds (EU). AC is supported by a PhD fellowship by Conselleria d'Educacio, Cultura i Universitats, Govern de les Illes Balears, a project which is cofinanced by the European Social Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science (PLOS) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Linoleic Acids, Conjugated | * |
dc.subject.mesh | Stomach | * |
dc.subject.mesh | Cecum | * |
dc.subject.mesh | Gastric Mucosa | * |
dc.subject.mesh | Mice, Inbred C57BL | * |
dc.subject.mesh | Real-Time Polymerase Chain Reaction | * |
dc.subject.mesh | Gastrointestinal Microbiome | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Leptin | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Protein Biosynthesis | * |
dc.subject.mesh | Ghrelin | * |
dc.subject.mesh | Diet, High-Fat | * |
dc.subject.mesh | Dietary Supplements | * |
dc.subject.mesh | Mice | * |
dc.title | Conjugated Linoleic Acid Supplementation under a High-Fat Diet Modulates Stomach Protein Expression and Intestinal Microbiota in Adult Mice | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 25915857 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | e0125091 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0125091 | |
dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0125091 | en |
dc.identifier.journal | PloS One | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Biosíntesis de Proteínas | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Microbioma Gastrointestinal | * |
dc.subject.decs | Ácidos Linoleicos Conjugados | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Mucosa Gástrica | * |
dc.subject.decs | Reacción en Cadena en Tiempo Real de la Polimerasa | * |
dc.subject.decs | Ciego | * |
dc.subject.decs | Ratones Endogémicos C57BL | * |
dc.subject.decs | Ghrelina | * |
dc.subject.decs | Ratones | * |
dc.subject.decs | Dieta Alta en Grasa | * |
dc.subject.decs | Suplementos Dietéticos | * |
dc.subject.decs | Leptina | * |
dc.subject.decs | Estómago | * |
dc.identifier.scopus | 2-s2.0-84928557624 | |
dc.identifier.wos | 353659100096 | |
dc.identifier.pui | L604006356 |
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