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dc.contributor.author | Pagonabarraga, Javier | |
dc.contributor.author | Pinol, Gerard | |
dc.contributor.author | Cardozo, Adriana | |
dc.contributor.author | Sanz, Pilar | |
dc.contributor.author | Puente, Victor | |
dc.contributor.author | Otermin, Pilar | |
dc.contributor.author | Legarda, Inés | |
dc.contributor.author | Delgado, Tania | |
dc.contributor.author | Serrano, Carmen | |
dc.contributor.author | Balaguer, Ernest | |
dc.contributor.author | Aguirregomozcorta, Maria | |
dc.contributor.author | Alvarez, Ramiro | |
dc.contributor.author | Kulisevsky, Jaime J. | |
dc.date.accessioned | 2024-07-04T12:54:49Z | |
dc.date.available | 2024-07-04T12:54:49Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Pagonabarraga J, Pinol G, Cardozo A, Sanz P, Puente V, Otermin P, et al. Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson's Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study. Parkinsons Dis. 2015;2015:131508. Epub 2015 Feb 22. | en |
dc.identifier.issn | 2090-8083 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/11033 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20088 | |
dc.description.abstract | Sleep disturbances occur frequently in patients with Parkinson's disease (PD). The aim of this study was to investigate the effects of rotigotine on sleep fluctuations in a sample of PD patients with self-reported complaints of nocturnal awakenings. This prospective, open-label, observational, and multicenter study enrolled consecutive outpatients with PD and administered rotigotine (mean dose 8.9 mg/day) for 3 months. The primary endpoint was the change from baseline in sleep fragmentation, assessed using the sleep maintenance subscale score of the Parkinson's Disease Sleep Scale (PDSS). The newly designed Parkinson's Disease Sleep Fragmentation Questionnaire (PD-SFQ) was used to measure other sleep parameters. A total of 62 patients were enrolled (mean age 70.2 years; 66% male). At 3 months, rotigotine significantly improved sleep fragmentation from baseline on the PDSS-2 sleep maintenance subscale (from 3.4 +/- 0.9 to 1.9 +/- 1.4; P < 0.0001). Rotigotine also significantly improved nocturnal motor symptoms (P < 0.0001), restless legs-like symptoms (P < 0.005), and nocturia (P = 0.004). Rotigotine significantly improved self-reported complaints of sleep fragmentation in PD patients and could be a useful treatment to improve this specific sleep problem in PD. However, these results are based on a small and clinically heterogeneous sample so they must be taken cautiously. | en |
dc.description.sponsorship | The authors wish to thank Simone Boniface of Springer Healthcare Communication and Raewyn Poole on behalf of Springer Healthcare Communications, for English editing and styling of the paper for submission. This assistance was funded by UCB Pharma, Spain. The study was funded by an unrestricted grant from UCB. UCB was not involved in the study design, the collection, analysis, and interpretation of the data gathered, the writing of the report, or the decision to submit the paper for publication. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Hindawi | en |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.title | Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson's Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study | en |
dc.type | research article | en |
dc.rights.license | Attribution 3.0 Unported | * |
dc.identifier.pubmedID | 25793143 | es_ES |
dc.format.volume | 2015 | es_ES |
dc.format.page | 131508 | es_ES |
dc.identifier.doi | 10.1155/2015/131508 | |
dc.identifier.e-issn | 2042-0080 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1155/2015/131508 | en |
dc.identifier.journal | Parkinsons Disease | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84924529872 | |
dc.identifier.wos | 351081200001 | |
dc.identifier.pui | L602813013 |
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