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dc.contributor.author | Maria Navarrete-Munoz, Eva | |
dc.contributor.author | Valera-Gran, Desiree | |
dc.contributor.author | Garcia de la Hera, Manoli | |
dc.contributor.author | Gimenez-Monzo, Daniel | |
dc.contributor.author | Morales, Eva | |
dc.contributor.author | Julvez, Jordi | |
dc.contributor.author | Riano, Isolina | |
dc.contributor.author | Tardon, Adonina | |
dc.contributor.author | Ibarluzea, Jesus | |
dc.contributor.author | Santa-Marina, Loreto | |
dc.contributor.author | Murcia, Mario | |
dc.contributor.author | Rebagliato, Marisa | |
dc.contributor.author | ||
dc.contributor.author | INMA Project | |
dc.date.accessioned | 2024-07-04T12:54:48Z | |
dc.date.available | 2024-07-04T12:54:48Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Navarrete-Muñoz EM, Valera-Gran D, Garcia De La Hera M, Gimenez-Monzo D, Morales E, Julvez J, et al. Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ Open. 2015;5(11):e009202. | en |
dc.identifier.issn | 2044-6055 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17188 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20085 | |
dc.description.abstract | Objectives: We examined the use of low (<400 mu g/day, including no use) and high folic acid supplement (FAS) dosages (>= 1000 mu g/day) among pregnant women in Spain, and explored factors associated with the use of these non-recommended dosages. Design: Population-based cohort study. Setting: Spain. Participants: We analysed data from 2332 pregnant women of the INMA study, a prospective mother-child cohort study in Spain. Main outcome measures: We assessed usual dietary folate and the use of FAS from preconception to the 3rd month (first period) and from the 4th to the 7th month (second period), using a validated food frequency questionnaire. We used multinomial logistic regression to estimate relative risk ratios (RRRs). Results: Over a half of the women used low dosages of FAS in the first and second period while 29% and 17% took high dosages of FAS, respectively. In the first period, tobacco smoking (RRR=1.63), alcohol intake (RRR=1.40), multiparous (RRR=1.44), unplanned pregnancy (RRR=4.20) and previous spontaneous abortion (RRR=0.58, lower use of high FAS dosages among those with previous abortions) were significantly associated with low FAS dosages. Alcohol consumption (RRR=1.42), unplanned pregnancy (RRR=2.66) and previous spontaneous abortion (RRR=0.68) were associated with high dosage use. In the second period, only tobacco smoking was significantly associated with high FAS dosage use (RRR=0.67). Conclusions: A high proportion of pregnant women did not reach the recommended dosages of FAS in periconception and a considerable proportion also used FAS dosages >= 1000 mu g/day. Action should be planned by the Health Care System and health professionals to improve the appropriate periconceptional use of FAS, taking into consideration the associated factors. | en |
dc.description.sponsorship | This study was funded by grants from Instituto de Salud Carlos III and Spanish Ministry of Health (Red INMA G03/176; CB06/02/0041; FIS 97/0588; 00/0021-2, PI061756; PS0901958; FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314; 09/02647; FIS-PI041436, FIS-PI081151, FIS-PI06/0867; FIS-PS09/00090, FIS-PI042018, FIS-PI09 02311, FIS PI11/01007, FISPI13/02429) Universidad de Oviedo, Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya-CIRIT 1999SGR 00241, Department of Health of the Basque Government (2005111093 and 2009111069) and the Provincial Government of Guipuzcoa (DFG06/004 and DFG08/001). | es_ES |
dc.language.iso | eng | en |
dc.publisher | BMJ Publishing Group | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject.mesh | Maternal Nutritional Physiological Phenomena | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Alcohol Drinking | * |
dc.subject.mesh | Pregnancy, Unplanned | * |
dc.subject.mesh | Spain | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Smoking | * |
dc.subject.mesh | Adolescent | * |
dc.subject.mesh | Abortion, Spontaneous | * |
dc.subject.mesh | Pregnancy | * |
dc.subject.mesh | Folic Acid | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Odds Ratio | * |
dc.subject.mesh | Prenatal Care | * |
dc.subject.mesh | Dietary Supplements | * |
dc.subject.mesh | Logistic Models | * |
dc.subject.mesh | Parity | * |
dc.title | Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial 4.0 International | * |
dc.identifier.pubmedID | 26603248 | es_ES |
dc.format.volume | 5 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | e009202 | es_ES |
dc.identifier.doi | 10.1136/bmjopen-2015-009202 | |
dc.relation.publisherversion | https://dx.doi.org/10.1136/bmjopen-2015-009202 | en |
dc.identifier.journal | BMJ Open | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Modelos Logísticos | * |
dc.subject.decs | Fenómenos Fisiologicos Nutricionales Maternos | * |
dc.subject.decs | Oportunidad Relativa | * |
dc.subject.decs | Ácido Fólico | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Embarazo no Planeado | * |
dc.subject.decs | Adolescente | * |
dc.subject.decs | Fumar | * |
dc.subject.decs | Aborto Espontáneo | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Estudios Prospectivos | * |
dc.subject.decs | Adulto Joven | * |
dc.subject.decs | Embarazo | * |
dc.subject.decs | Paridad | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Suplementos Dietéticos | * |
dc.subject.decs | Consumo de Bebidas Alcohólicas | * |
dc.subject.decs | Atención Prenatal | * |
dc.subject.decs | España | * |
dc.identifier.scopus | 2-s2.0-85006817994 | |
dc.identifier.wos | 368840100120 | |
dc.identifier.pui | L613789174 |
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