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dc.contributor.author | Capó Fiol, Xavier | |
dc.contributor.author | Martorell, Miquel | |
dc.contributor.author | Soldevila Verdeguer, Carla | |
dc.contributor.author | Tur, Josep A | |
dc.contributor.author | Pons, Antoni | |
dc.date.accessioned | 2024-07-04T12:54:47Z | |
dc.date.available | 2024-07-04T12:54:47Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Capo Fiol X, Martorell M, Sureda Gomila A, Tur J, Pons A. Effects of Docosahexaenoic Supplementation and In Vitro Vitamin C on the Oxidative and Inflammatory Neutrophil Response to Activation. Oxidative Med Cell Longev. 2015;2015:187849. Epub 2015 Apr 19. | en |
dc.identifier.issn | 1942-0900 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10993 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20084 | |
dc.description.abstract | We studied the effects of diet supplementation with docosahexaenoic (DHA) and in vitro vitamin C (VitC) at physiological concentrations on oxidative and inflammatory neutrophil response to phorbol myristate acetate (PMA). Fifteen male footballers ingested a beverage enriched with DHA or a placebo for 8 weeks in a randomized double-blind study. Neutrophils were isolated from blood samples collected in basal conditions at the end of nutritional intervention. Neutrophils were cultured for 2 hours at 37 degrees C in (a) control media, (b) media with PMA, and (c) media with PMA + VitC. PMA induces neutrophil degranulation with increased extracellular myeloperoxidase and catalase activities, nitric oxide production, expression of the inflammatory genes cyclooxygenase-2, nuclear factor kappa beta, interleukin 8 and tumor necrosis factor alpha, and interleukin 6 production. DHA diet supplementation boosts the exit of CAT from neutrophils but moderates the degranulation of myeloperoxidase granules induced by PMA. VitC facilitates azurophilic degranulation of neutrophils and increases gene expression of myeloperoxidase induced by PMA. VitC and DHA diet supplementation prevent PMA effects on inflammatory gene expression, although together they do not produce additional effects. DHA diet supplementation enhances antioxidant defences and anti-inflammatory neutrophil response to in vitro PMA activation. VitC facilitates neutrophil degranulation but prevents an inflammatory response to PMA. | en |
dc.description.sponsorship | This study was supported by Accion Estrategica en Salud del Ministro de Ciencia e Innovacion DPS2008-07033-C03-03, Programme of Promotion of Biomedical Research and Health Sciences, Projects 11/01791, Red Predimed-RETIC RD06/0045/1004, CIBERobn CB12/03/30038, and Balearic Island Government and FEDER funds (35/2011 and 23/2012). The authors hereby acknowledge the Ph.D. grant provided by the University of the Balearic Islands. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Hindawi | en |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject.mesh | Ascorbic Acid | * |
dc.subject.mesh | Oxidative Stress | * |
dc.subject.mesh | Neutrophil Activation | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Erythrocytes | * |
dc.subject.mesh | Gene Expression Regulation | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Inflammation | * |
dc.subject.mesh | Neutrophils | * |
dc.subject.mesh | Catalase | * |
dc.subject.mesh | Nitrates | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Nitrites | * |
dc.subject.mesh | Tetradecanoylphorbol Acetate | * |
dc.subject.mesh | Tumor Necrosis Factor-alpha | * |
dc.subject.mesh | Docosahexaenoic Acids | * |
dc.subject.mesh | Peroxidase | * |
dc.subject.mesh | Interleukin-6 | * |
dc.subject.mesh | Dietary Supplements | * |
dc.title | Effects of Docosahexaenoic Supplementation and In Vitro Vitamin C on the Oxidative and Inflammatory Neutrophil Response to Activation | en |
dc.type | research article | en |
dc.rights.license | Attribution 3.0 Unported | * |
dc.identifier.pubmedID | 25960826 | es_ES |
dc.format.volume | 2015 | es_ES |
dc.format.page | 187849 | es_ES |
dc.identifier.doi | 10.1155/2015/187849 | |
dc.identifier.e-issn | 1942-0994 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1155/2015/187849 | en |
dc.identifier.journal | Oxidative Medicine and Cellular Longevity | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Interleucina-6 | * |
dc.subject.decs | Peroxidasa | * |
dc.subject.decs | Ácidos Docosahexaenoicos | * |
dc.subject.decs | Acetato de Tetradecanoilforbol | * |
dc.subject.decs | Nitratos | * |
dc.subject.decs | Factor de Necrosis Tumoral alfa | * |
dc.subject.decs | Nitritos | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Catalasa | * |
dc.subject.decs | Regulación de la Expresión Génica | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Neutrófilos | * |
dc.subject.decs | Adulto Joven | * |
dc.subject.decs | Inflamación | * |
dc.subject.decs | Ácido Ascérbico | * |
dc.subject.decs | Estrés Oxidativo | * |
dc.subject.decs | Eritrocitos | * |
dc.subject.decs | Suplementos Dietéticos | * |
dc.subject.decs | Activación Neutrófila | * |
dc.identifier.scopus | 2-s2.0-84929378980 | |
dc.identifier.wos | 354738000001 | |
dc.identifier.pui | L604314822 |
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