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dc.contributor.author | Grases, Felix | |
dc.contributor.author | Prieto, Rafel M. | |
dc.contributor.author | Fernandez-Cabot, Rafel A. | |
dc.contributor.author | Costa-Bauza, Antonia | |
dc.contributor.author | Tur, Fernando | |
dc.contributor.author | Juan Torres-Rovira, Jose | |
dc.date.accessioned | 2024-07-04T12:54:44Z | |
dc.date.available | 2024-07-04T12:54:44Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Grases F, Prieto RM, Fernandez-Cabot RA, Costa-Bauza A, Tur F, Juan Torres J. Effects of Polyphenols from Grape Seeds on Renal Lithiasis. Oxidative Med Cell Longev. 2015;2015:813737. Epub 2015 Mar 25. | en |
dc.identifier.issn | 1942-0900 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10994 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20079 | |
dc.description.abstract | Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcification depends on preexisting injury and involves reactive oxygen species. Many plant extracts that protect against oxidative stressmanifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Rats were pretreated with polyphenols and grape seed extracts, followed by posterior induction of hyperoxalosis via treatment with ethylene glycol plus NH4Cl. The concentrations of calcium and other elements in kidney were determined, along with histological examination of kidney and 24 h urine analysis. Significant differences were observed in the renal calcium content between the control plus ethylene glycol-treated group and the epicatechin plus ethylene glycol-treated, red grape seed extract plus ethylene glycol-treated, and white grape seed extract plus ethylene glycol-treated groups, with reductions of about 50%. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation, particularly if calculi are induced by lesions caused by cytotoxic compounds with oxidative capacity. | en |
dc.description.sponsorship | This work was supported by the Project Grant, CTQ2010-18271, from the Ministerio de Ciencia e Innovacion (Gobierno de Espana), FEDER funds (European Union), and the Project Grant 9/2011 from the Conselleria d'Educacio, Cultura i Universitat (Govern de les Illes Balears). The authors are additionally grateful to Output Trade S.L. (Vilafranca del Penedes, Spain) for supplying the white grape seed extract. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Hindawi | en |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject.mesh | Ammonium Chloride | * |
dc.subject.mesh | Polyphenols | * |
dc.subject.mesh | Body Weight | * |
dc.subject.mesh | Calcium | * |
dc.subject.mesh | Kidney | * |
dc.subject.mesh | Lithiasis | * |
dc.subject.mesh | Vitis | * |
dc.subject.mesh | Kidney Diseases | * |
dc.subject.mesh | Catechin | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Rats, Wistar | * |
dc.subject.mesh | Magnesium | * |
dc.subject.mesh | Seeds | * |
dc.subject.mesh | Phosphorus | * |
dc.subject.mesh | Rats | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Ethylene Glycol | * |
dc.subject.mesh | Grape Seed Extract | * |
dc.title | Effects of Polyphenols from Grape Seeds on Renal Lithiasis | en |
dc.type | research article | en |
dc.rights.license | Attribution 3.0 Unported | * |
dc.identifier.pubmedID | 25883748 | es_ES |
dc.format.volume | 2015 | es_ES |
dc.format.page | 813737 | es_ES |
dc.identifier.doi | 10.1155/2015/813737 | |
dc.identifier.e-issn | 1942-0994 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1155/2015/813737 | en |
dc.identifier.journal | Oxidative Medicine and Cellular Longevity | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Glicol de Etileno | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Ratas Wistar | * |
dc.subject.decs | Litiasis | * |
dc.subject.decs | Enfermedades Renales | * |
dc.subject.decs | Catequina | * |
dc.subject.decs | Magnesio | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Riñón | * |
dc.subject.decs | Fósforo | * |
dc.subject.decs | Semillas | * |
dc.subject.decs | Polifenoles | * |
dc.subject.decs | Ratas | * |
dc.subject.decs | Vitis | * |
dc.subject.decs | Extracto de Semillas de Uva | * |
dc.subject.decs | Cloruro de Amonio | * |
dc.subject.decs | Calcio | * |
dc.subject.decs | Peso Corporal | * |
dc.identifier.scopus | 2-s2.0-84927153602 | |
dc.identifier.wos | 353489700001 | |
dc.identifier.pui | L603605510 |
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