dc.contributor.author | Frank, Matthias Johannes | |
dc.contributor.author | Walter, Martin S | |
dc.contributor.author | Rubert, Marina | |
dc.contributor.author | Thiede, Bernd | |
dc.contributor.author | Monjo, Marta | |
dc.contributor.author | Reseland, Janne E. | |
dc.contributor.author | Haugen, Havard Jostein | |
dc.contributor.author | Lyngstadaas, Stale Petter | |
dc.date.accessioned | 2024-07-03T11:01:26Z | |
dc.date.available | 2024-07-03T11:01:26Z | |
dc.date.issued | 2014-03 | |
dc.identifier.citation | Frank MJ, Walter Martin S, Rubert M, Thiede B, Monjo M, Reseland JE, et al. Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD). Materials. 2014 Mar;7(3):2210-28. | en |
dc.identifier.other | http://hdl.handle.net/20.500.13003/11313 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19975 | |
dc.description.abstract | The idea of a bioactive surface coating that enhances bone healing and bone growth is a strong focus of on-going research for bone implant materials. Enamel matrix derivate (EMD) is well documented to support bone regeneration and activates growth of mesenchymal tissues. Thus, it is a prime candidate for coating of existing implant surfaces. The aim of this study was to show that cathodic polarization can be used for coating commercially available implant surfaces with an immobilized but functional and bio-available surface layer of EMD. After coating, XPS revealed EMD-related bindings on the surface while SIMS showed incorporation of EMD into the surface. The hydride layer of the original surface could be activated for coating in an integrated one-step process that did not require any pre-treatment of the surface. SEM images showed nano-spheres and nano-rods on coated surfaces that were EMD-related. Moreover, the surface roughness remained unchanged after coating, as it was shown by optical profilometry. The mass peaks observed in the matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) analysis confirmed the integrity of EMD after coating. Assessment of the bioavailability suggested that the modified surfaces were active for osteoblast like MC3M3-E1 cells in showing enhanced Coll-1 gene expression and ALP activity. | en |
dc.description.sponsorship | This work was supported by the Norwegian Research Council (Grants No. 203034 and 203036) and by the Ministerio de Ciencia e Innovacion del Gobierno de Espana (Torres Quevedo contract to MR, and Ramon y Cajal contract to MM). The study materials, Ti and TiZr coins and EMD, were kindly provided by Institut Straumann AG, Basel, Switzerland. The authors are especially thankful for the excellent technical support and assistance from Martin Fleissner Sunding (Department of Physics, University of Oslo) for the XPS analysis, from Alexander Azarov (Centre for Materials Research, University of Oslo) for the SIMS analysis. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject | Bioactive coating | |
dc.subject | Coating technique | |
dc.subject | Enamel matrix derivate | |
dc.subject | EMD | |
dc.subject | Titanium | |
dc.subject | titanium-zirconium | |
dc.subject | Surface modification | |
dc.title | Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD) | en |
dc.type | research article | en |
dc.rights.license | Attribution 3.0 Unported | * |
dc.identifier.pubmedID | 28788564 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 2210-2228 | es_ES |
dc.identifier.doi | 10.3390/ma7032210 | |
dc.identifier.e-issn | 1996-1944 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.3390/ma7032210 | en |
dc.identifier.journal | Materials | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84897051621 | |
dc.identifier.wos | 336089500040 | |