Mostrar el registro sencillo del ítem
dc.contributor.author | Maria Torrens, Juana | |
dc.contributor.author | Orellana-Gavalda, Josep M | |
dc.contributor.author | Palou, Mariona | |
dc.contributor.author | Sanchez, Juana | |
dc.contributor.author | Herrero, Laura | |
dc.contributor.author | Picó, Catalina | |
dc.contributor.author | Serra, Dolors | |
dc.contributor.author | Palou, Andreu | |
dc.date.accessioned | 2024-07-03T11:01:18Z | |
dc.date.available | 2024-07-03T11:01:18Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Maria Torrens J, Orellana-Gavalda JM, Palou March M, Sánchez J, Herrero L, Pico C, et al. Enhancing Hepatic Fatty Acid Oxidation as a Strategy for Reversing Metabolic Disorders Programmed by Maternal Undernutrition During Gestation. Cell Physiol Biochem. 2014;33(5):1498-515. Epub 2014 May 14. | en |
dc.identifier.issn | 1015-8987 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/11863 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19959 | |
dc.description.abstract | Background/Aims: Moderate maternal calorie-restriction during gestation programmes offspring for a major propensity to develop metabolic alterations in adulthood. We aimed to assess whether increased hepatic fatty-acid oxidation (FAO), at early ages, by gene transfer of Cpt1am (active mutant of carnitine palmitoyltransferase-1a), may be a strategy for reversing metabolic disturbances associated to maternal calorie-restriction during gestation in rats. Methods: AAV-Gfp (control) and AAV-Cpt1am vectors were administered by tail vein injection in 18-day-old control-pups and the offspring of 20% calorie-restricted rats during gestation (CR). After weaning, animals were fed with normal-fat diet. At the age of 4 months, they were moved to HF-diet and sacrificed at the age of 6 months to collect tissues. Locomotive activity, energy expenditure and blood pressure were measured. Results: Under HF-diet, CR-animals showed higher HOMA-IR, adipocyte diameter and hepatic triglyceride accumulation than controls; these alterations were reverted in Cpt1am-injected animals. In liver, this treatment ameliorated inflammatory state, decreased expression of lipogenesis-related genes and partially restored the decreased expression of leptin-receptor occurring in CR-animals. Treatment also reverted the decreased energy expenditure and the increased blood pressure of CR-animals. Conclusion: Increasing hepatic FAO through AAV-Cpt1am injection at juvenile ages prevents some metabolic disorders associated to gestational maternal calorie-restriction. | en |
dc.description.sponsorship | We thank Enzo Ceresi for his help in morphological techniques. We gratefully acknowledge the Spanish Government (grant AGL2012-33692 to A. P., grant SAF2010-20039 to L. H. and grant SAF2011-30520-C02-01 to D. S.), the European Union (BIOCLAIMS FP7-244995 to A. P.), the Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), EFSD/Lilly and EFSD/Janssen (research fellowships to LH) and by L'Oreal-UNESCO (research fellowship to LH). The Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics) is a member of the European Research Network of Excellence NuGO (The European Nutrigenomics Organization, EU Contract: no FP6-506360). | es_ES |
dc.language.iso | eng | en |
dc.publisher | Karger Publishers | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | * |
dc.subject | Cpt1a | |
dc.subject | Calorie restriction | |
dc.subject | Gestation | |
dc.subject | Gene transference | |
dc.subject | Liver | |
dc.subject.mesh | Malnutrition | * |
dc.subject.mesh | Pregnancy, Animal | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Metabolic Diseases | * |
dc.subject.mesh | Carnitine O-Palmitoyltransferase | * |
dc.subject.mesh | Fatty Acids | * |
dc.subject.mesh | Fatty Liver | * |
dc.subject.mesh | Pregnancy | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Genetic Therapy | * |
dc.subject.mesh | Pregnancy Complications | * |
dc.subject.mesh | Rats, Wistar | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Rats | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Oxidation-Reduction | * |
dc.subject.mesh | Prenatal Exposure Delayed Effects | * |
dc.title | Enhancing Hepatic Fatty Acid Oxidation as a Strategy for Reversing Metabolic Disorders Programmed by Maternal Undernutrition During Gestation | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial 3.0 Unported | * |
dc.identifier.pubmedID | 24854839 | es_ES |
dc.format.volume | 33 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 1498-1515 | es_ES |
dc.identifier.doi | 10.1159/000358714 | |
dc.identifier.e-issn | 1421-9778 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1159/000358714 | en |
dc.identifier.journal | Cellular Physiology and Biochemistry | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Preñez | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Ratas Wistar | * |
dc.subject.decs | Terapia Genética | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Desnutrición | * |
dc.subject.decs | Enfermedades Metabólicas | * |
dc.subject.decs | Hígado Graso | * |
dc.subject.decs | Carnitina O-Palmitoiltransferasa | * |
dc.subject.decs | Ratas | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Ácidos Grasos | * |
dc.subject.decs | Complicaciones del Embarazo | * |
dc.subject.decs | Embarazo | * |
dc.subject.decs | Efectos Tardíos de la Exposición Prenatal | * |
dc.subject.decs | Oxidación-Reducción | * |
dc.identifier.scopus | 2-s2.0-84901334432 | |
dc.identifier.wos | 336493300022 | |
dc.identifier.pui | L373159366 |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |