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dc.contributor.author | Olmos, Gabriel | |
dc.contributor.author | Llado, Jeronia | |
dc.date.accessioned | 2024-07-03T11:01:18Z | |
dc.date.available | 2024-07-03T11:01:18Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Olmos Bonafe G, Llado Vich J. Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity. Mediat Inflamm. 2014;2014:861231. Epub 2014 May 21. | en |
dc.identifier.issn | 0962-9351 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/11404 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19958 | |
dc.description.abstract | Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system. In pathological conditions, microglia release large amounts of TNF-alpha; this de novo production of TNF-alpha is an important component of the so-called neuroinflammatory response that is associated with several neurological disorders. In addition, TNF-alpha can potentiate glutamate-mediated cytotoxicity by two complementary mechanisms: indirectly, by inhibiting glutamate transport on astrocytes, and directly, by rapidly triggering the surface expression of Ca+ 2 permeable-AMPA receptors and NMDA receptors, while decreasing inhibitory GABA(A) receptors on neurons. Thus, the net effect of TNF-alpha is to alter the balance of excitation and inhibition resulting in a higher synaptic excitatory/inhibitory ratio. This review summarizes the current knowledge of the cellular and molecular mechanisms by which TNF-alpha links the neuroinflammatory and excitotoxic processes that occur in several neurodegenerative diseases, but with a special emphasis on amyotrophic lateral sclerosis (ALS). As microglial activation and upregulation of TNF-alpha expression is a common feature of several CNS diseases, as well as chronic opioid exposure and neuropathic pain, modulating TNF-alpha signaling may represent a valuable target for intervention. | en |
dc.description.sponsorship | This work was supported by Grant Programa Pont la Caixa per a grups de recerca de la UIB to GO. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Hindawi | en |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject.mesh | Calcium | * |
dc.subject.mesh | Analgesics, Opioid | * |
dc.subject.mesh | Receptors, Glutamate | * |
dc.subject.mesh | Receptors, N-Methyl-D-Aspartate | * |
dc.subject.mesh | Astrocytes | * |
dc.subject.mesh | Receptors, AMPA | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Inflammation | * |
dc.subject.mesh | Neuralgia | * |
dc.subject.mesh | Neuroglia | * |
dc.subject.mesh | Synaptic Transmission | * |
dc.subject.mesh | Neurons | * |
dc.subject.mesh | Receptors, GABA-A | * |
dc.subject.mesh | Cytokines | * |
dc.subject.mesh | Neuronal Plasticity | * |
dc.subject.mesh | Tumor Necrosis Factor-alpha | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Signal Transduction | * |
dc.subject.mesh | Glutamic Acid | * |
dc.title | Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity | en |
dc.type | review article | en |
dc.rights.license | Attribution 3.0 Unported | * |
dc.identifier.pubmedID | 24966471 | es_ES |
dc.format.volume | 2014 | es_ES |
dc.format.page | 861231 | es_ES |
dc.identifier.doi | 10.1155/2014/861231 | |
dc.identifier.e-issn | 1466-1861 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1155/2014/861231 | en |
dc.identifier.journal | Mediators of Inflammation | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Transducción de Señal | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Ácido Glutámico | * |
dc.subject.decs | Citocinas | * |
dc.subject.decs | Factor de Necrosis Tumoral alfa | * |
dc.subject.decs | Neuronas | * |
dc.subject.decs | Plasticidad Neuronal | * |
dc.subject.decs | Astrocitos | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Neurogla | * |
dc.subject.decs | Transmisión Sinóptica | * |
dc.subject.decs | Receptores AMPA | * |
dc.subject.decs | Receptores de GABA-A | * |
dc.subject.decs | Inflamación | * |
dc.subject.decs | Neuralgia | * |
dc.subject.decs | Calcio | * |
dc.subject.decs | Receptores de Glutamato | * |
dc.subject.decs | Analgésicos Opioides | * |
dc.subject.decs | Receptores de N-Metil-D-Aspartato | * |
dc.identifier.scopus | 2-s2.0-84902144244 | |
dc.identifier.wos | 336614600001 | |
dc.identifier.pui | L373279697 |
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