dc.contributor.author | Martinez-Serra, Jordi | |
dc.contributor.author | del Campo Garcia, Raquel | |
dc.contributor.author | Gutierrez, Antonio | |
dc.contributor.author | Antich, Jose Luis | |
dc.contributor.author | Ginard, Magdalena | |
dc.contributor.author | Duran Pastor, Maria Antonia | |
dc.contributor.author | Bento, Leyre | |
dc.contributor.author | Ros, Teresa | |
dc.contributor.author | Amat, Juan C | |
dc.contributor.author | Vidal, Carmen | |
dc.contributor.author | Iglesias, Julio F | |
dc.contributor.author | Orlinska, Izabela | |
dc.contributor.author | Besalduch Vidal, Juan | |
dc.date.accessioned | 2024-07-03T11:01:15Z | |
dc.date.available | 2024-07-03T11:01:15Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Martinez-Serra J, Del Campo R, Gutierrez A, Antich JL, Ginard M, Duran MA, et al. Chronic myeloid leukemia with an e1a3 BCR-ABL fusion protein: transformation to lymphoid blast crisis.. Biomark Res. 2014;2:14. | en |
dc.identifier.issn | 2050-7771 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17107 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19952 | |
dc.description.abstract | Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph'). Most patients with CML express e13a2 or e14a2 mRNAs that result from a rearrangement of the major breakpoint cluster regions (M-BCR) generating the 210-kDa (p210BCR-ABL) fusion proteins b2a2 or b3a2 respectively. The e1a3 CML-related atypical translocation has been reported with an indolent clinical course, low leukocyte count, long chronic phase even without treatment and good response to therapy. We report the case of a patient initially diagnosed as CML in chronic phase whose cells expressed the e1a3 variant. The patient readily responded to imatinib 400mg with the achievement of a rapid complete cytogenetic response and the normalization of the blood count values, but after 5months transformed into lymphoid blast crisis. | en |
dc.language.iso | eng | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | ALL | |
dc.subject | CML | |
dc.subject | bcr-abl | |
dc.subject | e1a3 | |
dc.title | Chronic myeloid leukemia with an e1a3 BCR-ABL fusion protein: transformation to lymphoid blast crisis. | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 25197554 | es_ES |
dc.format.volume | 2 | es_ES |
dc.format.page | 14 | es_ES |
dc.identifier.doi | 10.1186/2050-7771-2-14 | |
dc.relation.publisherversion | https://dx.doi.org/10.1186/2050-7771-2-14 | en |
dc.identifier.journal | Biomarker Research | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-85006228432 | |
dc.identifier.pui | L603849551 | |