dc.contributor.author | Leiva Rus, Alfonso | |
dc.contributor.author | Aguilo, Antoni | |
dc.contributor.author | Fajo-Pascual, Marta | |
dc.contributor.author | Moreno, Lucia | |
dc.contributor.author | Martin, Ma Carmen | |
dc.contributor.author | Garcia, Elena Marina | |
dc.contributor.author | Duro Robles, Rosa Elena | |
dc.contributor.author | D'Agosto Forteza, Pilar | |
dc.contributor.author | Iglesias-Iglesias, Ana Aurelia | |
dc.contributor.author | Company, Rosa Maria | |
dc.contributor.author | Yañez, Aina M | |
dc.contributor.author | Llobera Cànaves, Joan | |
dc.date.accessioned | 2024-07-03T11:01:15Z | |
dc.date.available | 2024-07-03T11:01:15Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Leiva A, Aguilo A, Fajo-Pascual M, Moreno L, Martin MC, Garcia EM, et al. Efficacy of a brief multifactorial adherence-based intervention in reducing blood pressure: a randomized clinical trial. Patient Prefer Adherence. 2014;8:1683-90. | en |
dc.identifier.issn | 1177-889X | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17193 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19951 | |
dc.description.abstract | Background: Lowering blood pressure (BP) by antihypertensive (AHT) drugs reduces the risks of cardiovascular events, stroke, and total mortality. However, poor adherence to AHT medications reduces their effectiveness and increases the risk of adverse events. Objective: To evaluate the effectiveness of a multifactorial adherence-based intervention in a primary care setting in lowering BP. Methods/design: Multicenter parallel randomized controlled trial. Thirty two nurses in 28 primary care centers of three Spanish regions. Patients aged 18-80 years, taking AHT drugs with uncontrolled BP (n=221) were randomized to a control group (usual care) or a multifactorial adherence-based intervention including nurse-led motivational interviews, pill reminders, family support, BP self-recording, and simplification of the dosing regimen by a pharmacist. Main outcome measures: The primary outcome was 12-month blinded measure of systolic BP (mean of three measurements). The secondary outcomes were 12-month diastolic BP and proportion of patients with adequately controlled BP. Results: One hundred and fourteen patients were allocated to the intervention group and 109 to the control group. At 12 months, 212 (89%) participants completed the study. The systolic BP in the intervention group was 151.3 versus 153.7 in the control group (P=0.294). The diastolic BP did not differ between groups (83.4 versus 83.6). Of the patients in the control group, 9.2% achieved BP control versus a 15.8% in the intervention group. The relative risk for achieving BP control was 1.72 (95% confidence interval: 0.83-3.56). Conclusion: A multifactorial intervention based on improving adherence in patients with uncontrolled hypertension failed to find evidence of effectiveness in lowering systolic BP. | en |
dc.description.sponsorship | The Adherencia study was funded by the Carlos III Health Institute of the Ministry of Economy and Competitiveness of Spain (contract No PS09/01456). The Ministry had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, and approval of the manuscript or the decision to submit for publication.; This study was also supported by the Health Promotion and Preventive Activities - Primary Health Care Network, sustained by the Ministry of Health ISCIII-RETCI G03/170 and RD06/0018. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Dove Medical Press | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | * |
dc.subject | Hypertension | |
dc.subject | medication adherence | |
dc.subject | Blood pressure | |
dc.subject | Intervention studies | |
dc.title | Efficacy of a brief multifactorial adherence-based intervention in reducing blood pressure: a randomized clinical trial | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial 3.0 Unported | * |
dc.identifier.pubmedID | 25525344 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.page | 1683-1690 | es_ES |
dc.identifier.doi | 10.2147/PPA.S66927 | |
dc.relation.publisherversion | https://dx.doi.org/10.2147/PPA.S66927 | en |
dc.identifier.journal | Patient Preference and Adherence | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84916934673 | |
dc.identifier.wos | 346118200001 | |
dc.identifier.pui | L600739571 | |