dc.contributor.author | Jiménez-Martín, Débora | |
dc.contributor.author | García-Bocanegra, Ignacio | |
dc.contributor.author | Risalde, María A | |
dc.contributor.author | Napp, Sebastián | |
dc.contributor.author | Dominguez-Rodriguez, Mercedes | |
dc.contributor.author | Romero, Beatriz | |
dc.contributor.author | Moreno-Iruela, Inmaculada | |
dc.contributor.author | Martínez, Remigio | |
dc.contributor.author | Cano-Terriza, David | |
dc.date.accessioned | 2024-07-03T08:12:34Z | |
dc.date.available | 2024-07-03T08:12:34Z | |
dc.date.issued | 2024-06 | |
dc.identifier.citation | Prev Vet Med. 2024 Jun:227:106204. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19924 | |
dc.description.abstract | Tuberculosis (TB) is a zoonotic infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTC), which can affect a wide variety of domestic and wild animal species. Although the role of goats as a reservoir of MTC bacteria has been evidenced, information about the circulation of MTC strains in this species is still very scarce. The aim of the present study was to determine the seroprevalence, spatial distribution, risk factors and MTC spoligotypes circulating in goats from Andalusia (Southern Spain), the Spanish region with the largest goat census and a hotspot area of TB in both cattle and wild ungulates. A total of 2155 serum samples from 80 goat flocks were analyzed by an in-house ELISA using the P22 protein complex as a coating antigen. Antibodies against MTC were detected in 473 goats (21.9%, 95% CI: 20.2-23.7) and the true seroprevalence was 22.3% (95% CI: 20.6-24.1). Seropositivity was found in 72 (90.0%) of the 80 flocks analyzed. The generalized estimating equation model showed that the management system (higher seroprevalence on intensive and semi-intensive farms), and the presence of hospital pens inside the regular stables, were risk factors potentially associated with MTC exposure in goats in Southern Spain. The spatial analysis identified a significant spatial cluster (p < 0.001) in Eastern Andalusia. A total of 16 different MTC spoligotypes, including five of M. caprae and eleven of M. bovis, were identified in goats between 2015 and 2022 in the study area, with SB0157 as the most frequently isolated. The results obtained indicate widespread and non-homogeneous spatial distribution of MTC in goat herds from Southern Spain. The high individual and herd-level seroprevalence values found suggest that goats could play a significant role in the maintenance and transmission of MTC in the study area. Our results highlight the importance of implementing control measures in this species. | es_ES |
dc.description.sponsorship | We are grateful to the Spanish Ministry of Agriculture, Fisheries and Food for their support throughout this study. Part of this study has been awarded in 2023 with the "XXV Premio de Investigación Francisco Fernández López" sponsored by the Illustrious Official College of Veterinarians of Almería, Spain. This work is part of the AGL2013–49159-C2–2-R project, funded by the Spanish Ministry of Economy and Competitiveness (MINECO). This research was also supported by grant
from the University of Cordoba (REF: UCO-FEDER-1381385-R) and CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEUD. DJM was supported by a FPU grant (FPU22/03649) funded by the Spanish Ministry of Universities. RM acknowledges funding from the “Consejería de Transformación Económica, Industria, Conocimiento y Universidades” of the Regional
Government of Andalusia and the University of Córdoba (05yc77b46). Funding for open access charge: Universidad de Córdoba/CBUA. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Caprine | es_ES |
dc.subject | Risk factors | es_ES |
dc.subject | Surveillance | es_ES |
dc.subject | Spoligotypes | es_ES |
dc.subject | Tuberculosis | es_ES |
dc.subject | Zoonoses | es_ES |
dc.subject.mesh | Goats | es_ES |
dc.subject.mesh | Goat Diseases | es_ES |
dc.subject.mesh | Tuberculosis | es_ES |
dc.subject.mesh | Mycobacterium tuberculosis | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Seroepidemiologic Studies | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Prevalence | es_ES |
dc.title | Mycobacterium tuberculosis complex in domestic goats in Southern Spain | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución-NoComercial 4.0 Internacional | * |
dc.identifier.pubmedID | 38604014 | es_ES |
dc.format.volume | 227 | es_ES |
dc.format.page | 106204 | es_ES |
dc.identifier.doi | 10.1016/j.prevetmed.2024.106204 | es_ES |
dc.contributor.funder | Ministerio de Agricultura, Pesca y Alimentación (España) | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | University of Córdoba (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Universidades (España) | es_ES |
dc.contributor.funder | Regional Government of Andalusia (España) | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1873-1716 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.prevetmed.2024.106204 | es_ES |
dc.identifier.journal | Preventive veterinary medicine | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/UCO-FEDER-1381385-R | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/AGL2013-49159-C2–2-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU22/03649 | es_ES |