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Cohesin organizes chromatin loops at DNA replication factories.
journal article
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.
Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication.
USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication