dc.contributor.author | Medrano, Luz Maria | |
dc.contributor.author | Jiménez, José Luis | |
dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Fernández-Rodíguez, Amanda | |
dc.contributor.author | Gutiérrez-Rivas, Mónica | |
dc.contributor.author | Bellón, José María | |
dc.contributor.author | Blanco, José Ramón | |
dc.contributor.author | Inciarte, Alexy | |
dc.contributor.author | Muñoz-Fernández, Mª Ángeles | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2024-05-22T07:44:45Z | |
dc.date.available | 2024-05-22T07:44:45Z | |
dc.date.issued | 2017-10 | |
dc.identifier.citation | Eur J Clin Invest. 2017 Oct;47(10):719-727. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19515 | |
dc.description.abstract | Background: Our aim was to determine whether α-chain of the IL-7 receptor (IL7RA) polymorphisms (rs10491434, rs6897932 and rs987106) are associated with the clinical pattern of AIDS progression in ART-naïve HIV-infected patients. Materials and methods: We carried out a cross-sectional study in 673 HIV-infected patients who were classified into three groups according to the clinical pattern of AIDS progression (188 long-term nonprogressors (LTNPs), 334 moderate progressors (MPs) and 151 rapid progressors (RPs)). Additionally, 134 healthy blood donors participated as a Control-group. We selected three IL7RA polymorphisms located at three regulatory regions [rs6897932 (exon 6), rs987106 (intronic region) and rs10491434 (3'UTR)]. DNA genotyping was performed using Sequenom's MassARRAY platform. Results: The Control-group and all HIV-infected patients had similar age and percentage of males. LTNP-group was older at HIV diagnosis and at the inclusion in the study and had higher percentage of intravenous drug users (IDU) (P < 0·001). Besides, LTNP-group had lower proportion of male patients and homosexual HIV transmission than MP and RP groups (P < 0·001). Moreover, similar values of allelic, genotypic and haplotype frequencies for IL7RA polymorphisms were found between healthy controls and HIV-infected patients (P > 0·05), and among different subgroups of HIV patients according to AIDS progression (LTNPs, MPs and RPs) (P > 0·05). The adjusted logistic regression did not show any significant association between IL7RA polymorphisms and AIDS progression. Conclusions: IL7RA polymorphisms (rs6897932, rs987106 and rs10491434) were not associated with AIDS progression in Spanish population. Therefore, IL7RA polymorphisms do not seem to help us to understand HIV pathogenesis in untreated HIV-infected patients with different clinical evolution. | es_ES |
dc.description.sponsorship | This work has been (partially) funded by the RD12/0017/0037 and RD12/0017/0024 projects as part of the Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2008–2011 and cofinanced by Instituto de Salud Carlos III (Subdirección General de Evaluación) and Fondo Europeo de Desarrollo Regional (FEDER), RETIC PT13/0010/0028, Fondo de Investigación Sanitaria (FIS) (grant numbers PI13/02016, PI14/00882, PI14CIII/00011), Comunidad de Madrid (grant numbers S-2010/BMD-2351 and S-2010/BMD-2332), Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED) (grant numbers 214RT0482), and the ‘Programa de Investigación de la Consejería de Sanidad de la Comunidad de Madrid’ to JLJ.CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, the Consolider Programand CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work was supported partially by a Marie Curie International Research Staff Exchange Scheme Fellow-ship within the 7th European Community Framework Program, project No. PIRSES-GA-2012-316730 NANOGENE and cofinanced by the Polish Ministry of Science and Higher Education (grant No. W21/7PR/2013). LMM, MAJS and AFR are supported by ‘Instituto de Salud Carlos III’ [grant numbers CD14/00002, CD13/00013 and CP14/0010, respectively]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acquired immunodeficiency syndrome | es_ES |
dc.subject | IL7RA | es_ES |
dc.subject | Long-term nonprogressors | es_ES |
dc.subject | Progression | es_ES |
dc.subject | Singlenucleotide polymorphisms | es_ES |
dc.subject.mesh | Gene Expression Regulation | es_ES |
dc.subject.mesh | Polymorphism, Single Nucleotide | es_ES |
dc.subject.mesh | Acquired Immunodeficiency Syndrome | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Age Factors | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Disease Progression | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Interleukin-7 Receptor alpha Subunit | es_ES |
dc.subject.mesh | Logistic Models | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Prognosis | es_ES |
dc.subject.mesh | Reference Values | es_ES |
dc.subject.mesh | Risk Assessment | es_ES |
dc.subject.mesh | Sensitivity and Specificity | es_ES |
dc.subject.mesh | Sex Factors | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Survival Analysis | es_ES |
dc.title | IL7RA polymorphisms are not associated with AIDS progression | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 28796293 | es_ES |
dc.format.volume | 47 | es_ES |
dc.format.number | 10 | es_ES |
dc.format.page | 719-727 | es_ES |
dc.identifier.doi | 10.1111/eci.12797 | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Redes Temáticas de Investigación Cooperativa en Salud (RETICS) (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (España) | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERBBN (Bioingeniería, Biomateriales y Nanomedicina) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. 7 Programa Marco | es_ES |
dc.contributor.funder | Ministerio de Ciencia y Universidades (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1365-2362 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/eci.12797 | es_ES |
dc.identifier.journal | European journal of clinical investigation | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/316730/EU | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//RD12%2F0017%2F0037/ES/SIDA/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//RD12%2F0017%2F0024/ES/SIDA/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//PI13%2F02016/ES/Desarrollo y mecanismo de acción de dendrímeros como microbicidas para frenar la infección por el VIH por transmisión sexual (vaginal y anal): prueba de concepto/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//PI14%2F00882/ES/Prevención de la transmisión del VIH mediante el uso de la nanotecnología dirigida frente a proteínas virales, receptores celulares y DC-SIGN/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//CD14%2F00002/ES/CD14%2F00002/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CD13/00013 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//CP14%2F00100/ES/CP14%2F00100/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//PT13%2F0010%2F0028/ES/Plataforma de Biobancos/ | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/ISCIII Subprograma de proyectos de investigacion en salud . Modalidad proyectos en salud. (2014)/PI14CIII/00011 | es_ES |