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Título
IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART
Autor(es)
Guzman-Fulgencio, Maria ISCIII | Berenguer, Juan | Jimenez-Sousa, Maria Angeles ISCIII | Micheloud, Dariela | Garcia-Alvarez, Monica ISCIII | Bellón, José María | Aldámiz-Echevarría, Teresa | Garcia-Broncano, Pilar ISCIII | Catalán, Pilar | Diez, Cristina | Pineda-Tenor, Daniel ISCIII | Resino, Salvador ISCIII
Fecha de publicación
2015-11
Cita
Eur J Clin Invest. 2015 Nov;45(11):1192-9.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: The IL7RA polymorphisms have recently been associated with CD4+ T-cell decline in untreated HIV-infected subjects and CD4+ T-cell recovery in patients on combination antiretroviral therapy (cART). The aim of this study was to evaluate whether IL7RA polymorphisms are associated with CD4+ T-cell recovery in HIV-infected patients on long-term cART. Study design: We performed a retrospective study in 151 naïve cART patients with severe immunodeficiency (CD4+ counts ≤200 cells/mm(3) ). IL7RA polymorphisms' genotyping was performed using Sequenom's MassARRAY platform. The outcome variable was the time to achieve the first value of CD4+ count ≥500 cells/mm(3) during the follow-up. Results: Two different trends of CD4+ T-cell recovery were found in Kaplan-Meier analysis. During the first 48 months, 60 of 151 (39·7%) of the patients reached CD4+ T-cell values ≥500 cells/mm(3) , and no differences were observed between IL7RA genotypes. After the first 48 months of follow-up, 27 of 151 (17·8%) of the patients reached CD4+ T-cell values ≥500 cells/mm(3) , with a different pattern of CD4+ recovery depending on IL7RA genotype. Patients with rs10491434 TT genotype and rs6897932 TT genotype were more likely of achieving CD4+ value ≥500 cells/mm(3) than patients with rs10491434 CT/CC genotype (adjusted hazard ratio (aHR) = 3·59; P = 0·005) and patients with rs6897932 CC/CT genotype (aHR = 11·7; P < 0·001). Conclusions: The IL7RA polymorphisms seem to be associated with CD4+ T-cell recovery in HIV-infected patients who started cART with severe immunodeficiency, in the second phase of CD4+ T-cell recovery after long-term cART.
Palabras clave
MESH
Adult | Antiretroviral Therapy, Highly Active | CD4 Lymphocyte Count | CD4-Positive T-Lymphocytes | Female | Genotype | HIV Infections | HIV Protease Inhibitors | Humans | Kaplan-Meier Estimate | Male | Middle Aged | Polymorphism, Genetic | Polymorphism, Single Nucleotide | Proportional Hazards Models | Receptors, Interleukin-7 | Retrospective Studies | Reverse Transcriptase Inhibitors | Spain | Treatment Outcome | Viral Load
Versión en línea
DOI
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