Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19370
Título
Designing multitarget ligands for neurodegenerative diseases with improved permeability trough PLGA nanoencapsulation
Autor(es)
Fecha de publicación
2024-04-24
Cita
Biomed Pharmacother. 2024 Apr 24:175:116626.
Idioma
Inglés
Tipo de documento
research article
Resumen
Multitarget ligands (MTLs) have emerged as an interesting alternative for addressing complex multifactorial pathologies such as neurodegenerative diseases. However, a common challenge associated with these compounds is often their high molecular weight and low solubility, which becomes a hurdle when trying to permeate over the blood-brain barrier (BBB). In this study, we have designed two new MTLs that modulate three pharmacological targets simultaneously (tau, beta-amyloid and TAR DNA-binding protein 43). To enhance their brain penetration, we have formulated organic polymeric nanoparticles using poly(lactic-co-glycolic acid). The characterization of the formulations, evaluation of their permeability through an in vitro BBB model, and assessment of their activity on disease-representative cellular models, such as Alzheimer's disease and amyotrophic lateral sclerosis, have been conducted. The results demonstrate the potential of the new MTLs and their nanoparticle encapsulation for the treatment of neurodegenerative diseases.
Palabras clave
Multitarget ligand | Blood-brain barrier | Nanoparticles | Protein kinase inhibitors | Alzheimer’s disease | Amyotrophic lateral sclerosis
Versión en línea
DOI
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