dc.contributor.author | Cuervo, Henar | |
dc.contributor.author | Mühleder, Severin | |
dc.contributor.author | Garcia-Gonzalez, Irene | |
dc.contributor.author | Benedito, Rui | |
dc.date.accessioned | 2024-05-09T13:11:26Z | |
dc.date.available | 2024-05-09T13:11:26Z | |
dc.date.issued | 2023-12 | |
dc.identifier.citation | Curr Opin Cell Biol. 2023 Dec:85:102254. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19330 | |
dc.description.abstract | Vessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits the cell-cycle and metabolism of endothelial cells which coincides with the acquisition of arterial identity. During angiogenesis, the same molecular machinery prevents the hypermitogenic arrest and excessive sprouting of vessels. Notch also signals in pericytes and smooth muscle cells promoting vascular coverage and maturation. Here, we will review the latest findings on how Notch signals regulate the differentiation and interactions among vascular cells during organ development and homeostasis. | es_ES |
dc.description.sponsorship | Rui Benedito’s laboratory was supported by the European Research
Council (ERC) Consolidator Grant AngioUnrestUHD (101001814), the
Ministerio de Ciencia e Innovacio´n (PID2020-120252RB-I00) and “la
Caixa” Banking Foundation (HR22-00316). Henar Cuervo’s research was
supported by the Atraccio´n de Talento funding from the Comunidad
Auto´noma de Madrid (2020-T1/BMD-19985). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | CURRENT BIOLOGY LTD | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Endothelial Cells | es_ES |
dc.subject.mesh | Receptors, Notch | es_ES |
dc.subject.mesh | Cell Communication | es_ES |
dc.subject.mesh | Signal Transduction | es_ES |
dc.subject.mesh | Cell Differentiation | es_ES |
dc.subject.mesh | Neovascularization, Physiologic | es_ES |
dc.title | Notch-mediated cellular interactions between vascular cells. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 37832167 | es_ES |
dc.format.volume | 85 | es_ES |
dc.format.page | 102254 | es_ES |
dc.identifier.doi | 10.1016/j.ceb.2023.102254 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1879-0410 | es_ES |
dc.relation.publisherversion | 10.1016/j.ceb.2023.102254 | es_ES |
dc.identifier.journal | Current opinion in cell biology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Molecular de la Angiogénesis | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/Consolidator_Grant/101001814 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-120252RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR22-00316 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2020-T1/BMD-19985 | es_ES |