Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/19330
Title
Notch-mediated cellular interactions between vascular cells.
Author(s)
Date issued
2023-12
Citation
Curr Opin Cell Biol. 2023 Dec:85:102254.
Language
Inglés
Document type
journal article
Abstract
Vessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits the cell-cycle and metabolism of endothelial cells which coincides with the acquisition of arterial identity. During angiogenesis, the same molecular machinery prevents the hypermitogenic arrest and excessive sprouting of vessels. Notch also signals in pericytes and smooth muscle cells promoting vascular coverage and maturation. Here, we will review the latest findings on how Notch signals regulate the differentiation and interactions among vascular cells during organ development and homeostasis.
MESH
Endothelial Cells | Receptors, Notch | Cell Communication | Signal Transduction | Cell Differentiation | Neovascularization, Physiologic
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DOI
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