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dc.contributor.author | Culemann, Stephan | |
dc.contributor.author | Knab, Katharina | |
dc.contributor.author | Euler, Maximilien | |
dc.contributor.author | Wegner, Anja | |
dc.contributor.author | Garibagaoglu, Hilal | |
dc.contributor.author | Ackermann, Jochen | |
dc.contributor.author | Fischer, Kim | |
dc.contributor.author | Kienhöfer, Deborah | |
dc.contributor.author | Crainiciuc, Georgiana | |
dc.contributor.author | Hahn, Jonas | |
dc.contributor.author | Grüneboom, Anika | |
dc.contributor.author | Nimmerjahn, Falk | |
dc.contributor.author | Uderhardt, Stefan | |
dc.contributor.author | Hidalgo, Andres | |
dc.contributor.author | Schett, Georg | |
dc.contributor.author | Hoffmann, Markus H | |
dc.contributor.author | Krönke, Gerhard | |
dc.date.accessioned | 2024-05-08T09:38:59Z | |
dc.date.available | 2024-05-08T09:38:59Z | |
dc.date.issued | 2023-06-05 | |
dc.identifier.citation | J Exp Med. 2023 Jun 5;220(6):e20220525. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19290 | |
dc.description.abstract | Clodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) to study the function of these cells in vivo. Here, we revisited the effects of Clo-Lip together with genetic models of MoPh deficiency, revealing that Clo-Lip exert their anti-inflammatory effects independent of MoPh. Notably, not only MoPh but also polymorphonuclear neutrophils (PMN) ingested Clo-Lip in vivo, which resulted in their functional arrest. Adoptive transfer of PMN, but not of MoPh, reversed the anti-inflammatory effects of Clo-Lip treatment, indicating that stunning of PMN rather than depletion of MoPh accounts for the anti-inflammatory effects of Clo-Lip in vivo. Our data highlight the need for a critical revision of the current literature on the role of MoPh in inflammation. | es_ES |
dc.description.sponsorship | This work was supported by the Deutsche Forschungsgemeinschaft (FG 2886 “PANDORA” – B01/B02/A03/ B04 to G. Kronke, F. Nimmerjahn, G. Schett, and M.H. Hoff- ¨ mann, respectively, and the CRC1181-A03/A01/A02/A07/C03 Z2 to G. Kronke, G. Schett, F. Nimmerjahn, and M.H. Hoffmann), ¨ the Emerging Field Initiative of the Friedrich-Alexander University Erlangen-Nürnberg (EFI_Verbund_Med_05_MIRACLE to G. Kronke), the Bundesministerium für Bildung und For- ¨ schung (MASCARA to G. Kronke and G. Schett; MelAutim to G. ¨ Kronke), and the European Union (Horizon 2020 ERC-2014-StG ¨ 640087 – SOS and ERC-2020-CoG 101001866 – INSPIRE to G. Kronke; and ERC-2018-SyG nanoSCOPE and RTCure to G. ¨ Schett). This work was supported by grants R01AI165661 from the National Institutes of Health/National Institute of Allergy and Infectious Diseases, H2020-FET-OPEN-2018- 2020 (no. 861878) from the European Commission to A. Hidalgo and M.H. Hoffmann, and HR17_00527 from Fundacion La Caixa to A. Hidalgo. The CNIC is supported by the Ministerio de Ciencia e Innovacion and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MICINN award CEX2020-001041-S). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Rockefeller University Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject.mesh | Liposomes | es_ES |
dc.subject.mesh | Clodronic Acid | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Neutrophils | es_ES |
dc.subject.mesh | Inflammation | es_ES |
dc.subject.mesh | Anti-Inflammatory Agents | es_ES |
dc.title | Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 36976180 | es_ES |
dc.format.volume | 220 | es_ES |
dc.format.number | 6 | es_ES |
dc.identifier.doi | 10.1084/jem.20220525 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1540-9538 | es_ES |
dc.relation.publisherversion | 10.1084/jem.20220525 | es_ES |
dc.identifier.journal | The Journal of experimental medicine | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC-2014-StG/640087 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC-2020-CoG/101001866 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC-2018-SyG/nanoSCOPE | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17/00527 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |