Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19290
Título
Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.
Autor(es)
Culemann, Stephan | Knab, Katharina | Euler, Maximilien | Wegner, Anja | Garibagaoglu, Hilal | Ackermann, Jochen | Fischer, Kim | Kienhöfer, Deborah | Crainiciuc, Georgiana CNIC | Hahn, Jonas | Grüneboom, Anika | Nimmerjahn, Falk | Uderhardt, Stefan | Hidalgo, Andres CNIC | Schett, Georg | Hoffmann, Markus H | Krönke, Gerhard
Fecha de publicación
2023-06-05
Cita
J Exp Med. 2023 Jun 5;220(6):e20220525.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Clodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) to study the function of these cells in vivo. Here, we revisited the effects of Clo-Lip together with genetic models of MoPh deficiency, revealing that Clo-Lip exert their anti-inflammatory effects independent of MoPh. Notably, not only MoPh but also polymorphonuclear neutrophils (PMN) ingested Clo-Lip in vivo, which resulted in their functional arrest. Adoptive transfer of PMN, but not of MoPh, reversed the anti-inflammatory effects of Clo-Lip treatment, indicating that stunning of PMN rather than depletion of MoPh accounts for the anti-inflammatory effects of Clo-Lip in vivo. Our data highlight the need for a critical revision of the current literature on the role of MoPh in inflammation.
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- Nombre:
- Stunning of neutrophils_J Exp ...
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