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Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.

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dc.contributor.authorCulemann, Stephan
dc.contributor.authorKnab, Katharina
dc.contributor.authorEuler, Maximilien
dc.contributor.authorWegner, Anja
dc.contributor.authorGaribagaoglu, Hilal
dc.contributor.authorAckermann, Jochen
dc.contributor.authorFischer, Kim
dc.contributor.authorKienhöfer, Deborah
dc.contributor.authorCrainiciuc, Georgiana
dc.contributor.authorHahn, Jonas
dc.contributor.authorGrüneboom, Anika
dc.contributor.authorNimmerjahn, Falk
dc.contributor.authorUderhardt, Stefan
dc.contributor.authorHidalgo, Andres
dc.contributor.authorSchett, Georg
dc.contributor.authorHoffmann, Markus H
dc.contributor.authorKrönke, Gerhard
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)es_ES
dc.contributor.funderNational Institutes of Health (Estados Unidos)es_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.date.accessioned2024-05-08T09:38:59Z
dc.date.available2024-05-08T09:38:59Z
dc.date.issued2023-06-05
dc.description.abstractClodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) to study the function of these cells in vivo. Here, we revisited the effects of Clo-Lip together with genetic models of MoPh deficiency, revealing that Clo-Lip exert their anti-inflammatory effects independent of MoPh. Notably, not only MoPh but also polymorphonuclear neutrophils (PMN) ingested Clo-Lip in vivo, which resulted in their functional arrest. Adoptive transfer of PMN, but not of MoPh, reversed the anti-inflammatory effects of Clo-Lip treatment, indicating that stunning of PMN rather than depletion of MoPh accounts for the anti-inflammatory effects of Clo-Lip in vivo. Our data highlight the need for a critical revision of the current literature on the role of MoPh in inflammation.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by the Deutsche Forschungsgemeinschaft (FG 2886 “PANDORA” – B01/B02/A03/ B04 to G. Kronke, F. Nimmerjahn, G. Schett, and M.H. Hoff- ¨ mann, respectively, and the CRC1181-A03/A01/A02/A07/C03 Z2 to G. Kronke, G. Schett, F. Nimmerjahn, and M.H. Hoffmann), ¨ the Emerging Field Initiative of the Friedrich-Alexander University Erlangen-Nürnberg (EFI_Verbund_Med_05_MIRACLE to G. Kronke), the Bundesministerium für Bildung und For- ¨ schung (MASCARA to G. Kronke and G. Schett; MelAutim to G. ¨ Kronke), and the European Union (Horizon 2020 ERC-2014-StG ¨ 640087 – SOS and ERC-2020-CoG 101001866 – INSPIRE to G. Kronke; and ERC-2018-SyG nanoSCOPE and RTCure to G. ¨ Schett). This work was supported by grants R01AI165661 from the National Institutes of Health/National Institute of Allergy and Infectious Diseases, H2020-FET-OPEN-2018- 2020 (no. 861878) from the European Commission to A. Hidalgo and M.H. Hoffmann, and HR17_00527 from Fundacion La Caixa to A. Hidalgo. The CNIC is supported by the Ministerio de Ciencia e Innovacion and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MICINN award CEX2020-001041-S).es_ES
dc.format.number6es_ES
dc.format.volume220es_ES
dc.identifier.citationJ Exp Med. 2023 Jun 5;220(6):e20220525.es_ES
dc.identifier.doi10.1084/jem.20220525es_ES
dc.identifier.e-issn1540-9538es_ES
dc.identifier.journalThe Journal of experimental medicinees_ES
dc.identifier.pubmedID36976180es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/19290
dc.language.isoenges_ES
dc.publisherRockefeller University Presses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/HR17/00527es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/CEX2020-001041-Ses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ERC-2014-StG/640087es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ERC-2020-CoG/101001866es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ERC-2018-SyG/nanoSCOPEes_ES
dc.relation.publisherversion10.1084/jem.20220525es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subject.meshLiposomeses_ES
dc.subject.meshClodronic Acides_ES
dc.subject.meshHumanses_ES
dc.subject.meshNeutrophilses_ES
dc.subject.meshInflammationes_ES
dc.subject.meshAnti-Inflammatory Agentses_ES
dc.titleStunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication18d7e8cb-2cd8-4c07-8da8-81d3503c749f
relation.isAuthorOfPublicationacb8e30b-34b9-4718-b517-8d5962f70950
relation.isAuthorOfPublication.latestForDiscovery18d7e8cb-2cd8-4c07-8da8-81d3503c749f

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