Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19013
Título
Genomic Surveillance Uncovers a 10-Year Persistence of an OXA-24/40 Acinetobacter baumannii Clone in a Tertiary Hospital in Northern Spain
Autor(es)
Fecha de publicación
2024-02-16
Cita
Int J Mol Sci. 2024 Feb 16;25(4):2333.
Idioma
Inglés
Tipo de documento
research article
Resumen
Infections caused by carbapenem-resistant Acinetobacter baumannii are a global threat causing a high number of fatal infections. This microorganism can also easily acquire antibiotic resistance determinants, making the treatment of infections a big challenge, and has the ability to persist in the hospital environment under a wide range of conditions. The objective of this work was to study the molecular epidemiology and genetic characteristics of two blaOXA24/40Acinetobacter baumannii outbreaks (2009 and 2020-21) at a tertiary hospital in Northern Spain. Thirty-six isolates were investigated and genotypically screened by Whole Genome Sequencing to analyse the resistome and virulome. Isolates were resistant to carbapenems, aminoglycosides and fluoroquinolones. Multi-Locus Sequence Typing analysis identified that Outbreak 1 was mainly produced by isolates belonging to ST3Pas/ST106Oxf (IC3) containing blaOXA24/40, blaOXA71 and blaADC119. Outbreak 2 isolates were exclusively ST2Pas/ST801Oxf (IC2) blaOXA24/40, blaOXA66 and blaADC30, the same genotype seen in two isolates from 2009. Virulome analysis showed that IC2 isolates contained genes for capsular polysaccharide KL32 and lipooligosacharide OCL5. A 8.9 Kb plasmid encoding the blaOXA24/40 gene was common in all isolates. The persistance over time of a virulent IC2 clone highlights the need of active surveillance to control its spread.
Palabras clave
Acinetobacter baumannii | Carbapenem resistance | Hospital outbreaks | Sequencing | Plasmid | Persistence
MESH
Bacterial Proteins | Acinetobacter baumannii | Multilocus Sequence Typing | Tertiary Care Centers | Spain | Microbial Sensitivity Tests | Anti-Bacterial Agents | Genomics | beta-Lactamases
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