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dc.contributor.author | Domingo-Relloso, Arce | |
dc.contributor.author | Jerolon, Allan | |
dc.contributor.author | Tellez-Plaza, Maria | |
dc.contributor.author | Bermudez, Jose D | |
dc.date.accessioned | 2024-03-19T08:08:38Z | |
dc.date.available | 2024-03-19T08:08:38Z | |
dc.date.issued | 2024-02-18 | |
dc.identifier.citation | medRxiv. 2024 Feb 18:2024.02.16.24302923. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19002 | |
dc.description.abstract | Objective: The study of the potential intermediate effect of several variables on the association between an exposure and a time-to-event outcome is a question of interest in epidemiologic research. However, to our knowledge, no tools have been developed for the evaluation of multiple correlated mediators in a survival setting. Methods: In this work, we extended the multimediate algorithm, which conducts mediation analysis in the context of multiple uncausally correlated mediators, to a time-to-event setting using the semiparametric additive hazards model. We theoretically demonstrated that, under certain assumptions, indirect, direct and total effects can be calculated using the counterfactual framework with collapsible survival models. We also adapted the algorithm to accommodate exposure-mediator interactions. Results and conclusions: Using simulations, we demonstrated that our algorithm performs better than the product of coefficients method, even for uncorrelated mediators. The additive hazards model quantifies the effects as rate differences, which constitute a measure of impact, with applications that can be highly informative for public health. Our algorithm can be found in the R package multimediate, which is available in Github. | es_ES |
dc.description.sponsorship | ADR was supported by a fellowship from “la Caixa” Foundation (ID 100010434) (fellowship code “LCF/BQ/DR19/11740016”), and by the National Institute of Environmental Health Sciences of the United States (P42ES033719). Dr. Tellez-Plaza received funding from the Strategic Action for Research in Health sciences (CP12/03080 and PI15/00071), which are initiatives from Instituto de Salud Carlos III and the Spanish Ministry of Science and Innovation and co-funded with European Funds for Regional Development (FEDER) and by the State Agency for Research (PID2019-108973RB-C21). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | medRxiv | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Mediation analysis | es_ES |
dc.subject | Survival analysis | es_ES |
dc.subject | Correlated mediators | es_ES |
dc.subject | Additive models | es_ES |
dc.title | Causal mediation for uncausally related mediators in the context of survival analysis | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38405856 | es_ES |
dc.format.page | 2024.02.16.24302923 | es_ES |
dc.identifier.doi | 10.1101/2024.02.16.24302923 | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | NIH - National Institute of Environmental Health Sciences (NIEHS) (Estados Unidos) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.description.peerreviewed | No | es_ES |
dc.relation.publisherversion | https://doi.org/10.1101/2024.02.16.24302923 | es_ES |
dc.identifier.journal | medRxiv : the preprint server for health sciences | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//CP12%2F03080/ES/CP12%2F03080/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//PI15%2F00071/ES/Metales y arteriosclerosis subclínica: papel de la variación genética y epigenética en genes candidatos/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-108973RB-C21 | es_ES |