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dc.contributor.author | López-Otín, Carlos | |
dc.contributor.author | Blasco, MA | |
dc.contributor.author | Partridge, Linda | |
dc.contributor.author | Serrano, Manuel | |
dc.contributor.author | Kroemer, Guido | |
dc.date.accessioned | 2024-03-18T11:08:07Z | |
dc.date.available | 2024-03-18T11:08:07Z | |
dc.date.issued | 2023-01-19 | |
dc.identifier.citation | Cell . 2023 ;186(2):243-278. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/18979 | |
dc.description.abstract | Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress. | es_ES |
dc.description.sponsorship | We apologize for omitting relevant works and citations due to space constraints. We acknowledge all members of our laboratories for helpful comments during the elaboration of this manuscript. We thank JoseM.P. Freije for critical reading of the manuscript. C.L-O. is supported by grants from the European Research Council (ERC Advanced Grant, DeAge), Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III, and La Caixa Foundation (HR17-00221). The Instituto Universitario de Oncologia is supported by Fundacion Bancaria Caja de Ahorros de Asturias. M.B. is funded by Agencia Estatal de Investigacion (AEI/MCI/10.13039/501100011033, project RETOS SAF2017-82623-R), cofunded by European Regional Development Fund, "A way of making Europe"; Comunidad de Madrid with the Sinergy Project COVIDPREclinicalMODels-CM and the ERC under the European Union's Horizon 2020 research and innovation programme (grant 882385) through the project ERC-AvG SHELTERINS. The CNIO, certified as Severo Ochoa Centre of Excellence by AEI/MCI/10.13039/501100011033, is supported by the Spanish Government through the Instituto de Salud Carlos III. L.P. is supported by Horizon 2020 Framework Programme 741989, the Max Planck Society, and the BBSRC. M.S. is funded by a core grant from the IRB, La Caixa Foundation, the Milky Way Research Foundation, and Secretaria d'Universitats i Recerca del Departament d'Empresa i Coneixement of Catalonia (Grup de Recerca Consolidat 2017 SGR 282). G.K. is supported by the Ligue contre le Cancer (equipe labellisee); Agence National de la Recherche (ANR)-Projets blancs; AMMICa US23/CNRS UMS3655; Association pour la recherche sur le cancer (ARC); Canceropole Ile-de-France; Fondation pour la Recherche Medicale (FRM); a donation by Elior; Equipex Onco-Pheno-Screen; European Joint Programme on Rare Diseases; the European Union Horizon 2020 Projects Oncobiome and Crimson; Fondation Carrefour; Institut National du Cancer; Institut Universitaire de France; LabEx Immuno-Oncology (ANR-18-IDEX-0001); a Cancer Research ASPIRE Award from the Mark Foundation; the RHU Immunolife; Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); and SIRIC Cancer Research and Personalized Medicine (CARPEM). This study contributes to the IdEx Universitede Paris ANR-18-IDEX-0001. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Aging | es_ES |
dc.subject.mesh | Cellular Senescence | es_ES |
dc.subject.mesh | Epigenesis, Genetic | es_ES |
dc.subject.mesh | Proteostasis | es_ES |
dc.subject.mesh | Stem Cells | es_ES |
dc.title | Hallmarks of aging: An expanding universe. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 36599349 | es_ES |
dc.format.volume | 186 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 243 | es_ES |
dc.identifier.doi | 10.1016/j.cell.2022.11.001 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Fundación Bancaria Caja de Ahorros de Asturias | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Max Planck Society | es_ES |
dc.contributor.funder | UK Research and Innovation | es_ES |
dc.contributor.funder | Agence Nationale de la Recherche (Francia) | es_ES |
dc.contributor.funder | Government of Catalonia (España) | es_ES |
dc.contributor.funder | Fondation ARC pour la recherche sur le cancer | es_ES |
dc.contributor.funder | IdEx Universitede Paris | es_ES |
dc.contributor.funder | SIRIC Cancer Research and Personalized Medicine (CARPEM) | es_ES |
dc.contributor.funder | SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE) | es_ES |
dc.contributor.funder | Seerave Foundation | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1097-4172 | es_ES |
dc.relation.publisherversion | https://doi.org/ 10.1016/j.cell.2022.11.001. | es_ES |
dc.identifier.journal | Cell | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Grupo de Telómeros y Telomerasa | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/882385/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/741989/EU | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/SAF2017-82623-R | es_ES |