Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/18634
Título
Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance.
Autor(es)
Fecha de publicación
2022-04-30
Idioma
Inglés
Tipo de documento
research article
Resumen
Nowadays, the identification of new therapeutic targets that allow for the development of treatments, which as monotherapy, or in combination with other existing treatments can contribute to improve response rates, prognosis and survival of oncologic patients, is a priority to optimize healthcare within sustainable health systems. Recent studies have demonstrated the role of Substance P (SP) and its preferred receptor, Neurokinin 1 Receptor (NK-1R), in human cancer and the potential antitumor activity of NK-1R antagonists as an anticancer treatment. In this review, we outline the relevant studies published to date regarding the SP/NK-1R complex as a key player in human cancer and also evaluate if the repurposing of already marketed NK-1R antagonists may be useful in the development of new treatment strategies to overcome cancer resistance.
Palabras clave
NK-1R | cancer | drug repurposing | personalized medicine | resistance | tachykinin | tachykinin receptor | targeted treatment
DOI
Aparece en las colecciones
Acceso a texto completo