Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/18513
Título
Effect on an Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate and Vitamin D on Morphofunctional Aspects, Body Composition, and Phase Angle in Malnourished Patients
Autor(es)
Fecha de publicación
2021-12-03
Idioma
Inglés
Tipo de documento
research article
Resumen
This is a retrospective study of data from clinical practice to observe the effect of a high-calorie, high-protein oral nutritional supplement (ONS) with β-hydroxy-β-methylbutyrate (HMB) on nutritional status, body weight, and muscle-related parameters in 283 adult patients with or at risk of malnutrition under standard of care, 63% being cancer patients. They were recommended to increase physical activity and energy and protein intake from regular diet plus two servings per day of a specialized ONS enriched with HMB or standard ONS for up to 6 months. Dietary records, adherence and tolerance to ONS, nutritional status, body composition, handgrip strength, and blood analysis at the beginning and the end of the intervention were recorded. This program improved nutritional status from 100% malnourished or at risk of malnutrition at baseline to 80% well-nourished at final visit. It also increased body weight by 3.6-3.8 kg, fat-free mass by 0.9 to 1.3 kg, and handgrip strength by 4.7 to 6.2 kg. In a subgroup of patients (n = 43), phase angle (PhA), and body cell mass (BCM) increased only in the patients receiving the ONS enriched with HMB (0.95 (0.13) vs. -0.36 (0.4), and 2.98 (0.5) vs. -0.6 (1.5) kg, mean difference (SE) from baseline for PhA and BCM, respectively), suggesting the potential efficacy of this supplement on muscle health.
Palabras clave
Malnutrition | Muscle loss | Oral nutritional supplements | Cancer | β-hydroxy-β-methylbuty rate | Phase angle | Body cell mass | Nutritional status | Body composition | Body weight | Vitamin D | Desnutrición | Músculos | Suplementos dietéticos | Neoplasias | Estado nutricional | Composición corporal | Peso corporal | Vitamina D
MESH
Administration, Oral | Body Composition | Body Weight | Dietary Proteins | Eating | Energy Intake | Female | Hand Strength | Humans | Male | Malnutrition | Middle Aged | Neoplasms | Nutritional Physiological Phenomena | Retrospective Studies | Time Factors | Valerates | Vitamin D | Dietary Supplements | Adult | Nutritional Status | Diet Records | Standard of Care | Diet | Exercise | Muscles
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