Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/18356
Título
DEPTOR in Skeletal Development and Diseases
Autor(es)
Fecha de publicación
2021-05-27
Idioma
Inglés
Tipo de documento
review article
Resumen
Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTORdependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease.
Palabras clave
DEPTOR | mTOR | Skeleton | Bone | Cartilage | Proteína reguladora asociada a mTOR | Diana mecanicista del complejo 1 de la rapamicina | Esqueleto | Huesos | Cartílago
MESH
Bone and Bones | Sirolimus | Homeostasis | Biology | Animals | Chromosomes, Human, Pair 8 | PDZ Domains | TOR Serine-Threonine Kinases | Signal Transduction | Cell Membrane | Cytological Techniques
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