dc.description.abstract | Introduction: Less than one-third of bladder cancers are non-pure urothelial carcinoma [with variant histological (VH) or non-urothelial carcinoma (non-UC)] for which no treatment guidelines are available. We aim to evaluate the efficacy of systemic treatments in VH or non-UC bladder cancers. Materials: Multicenter retrospective analysis of patients treated for advanced or metastatic VH or non-UC bladder cancers. Primary endpoint was overall response rate (ORR) according to treatment line, regimen and histology subtype. Secondary endpoints were progression-free survival (PFS) and overall survival (OS). Results: Between 2005 and 2020, 46 patients from seven centers were included. The median age was 66 years (58.75; 74.75), 65.2% were male and 67.2% presented VH. At first line, the ORR for the entire population was 54.4% and median OS was 21.6 months (95% confidence interval [CI]: 14.2-38.6). The ORR of the 37 patients treated with chemotherapy at first line was 62.2% with median PFS and OS of 7.3 (95% CI: 4.5-8.6) and 21.6 months (95% CI: 14.2-35.7), respectively. Dose dense MVAC and platinum doublet chemotherapy had the highest ORR (71.4% and 65.2%). The 9 patients treated with immunotherapy at first line had an ORR of 22.2%, a median PFS of 3.3 months (95% CI:2.3-NR) and the median OS was not reached (95% CI:13.8-NR). Response to treatment varied depending on the histological sub-types and on the treatment type. Conclusion: Chemotherapy and immunotherapy have shown to be effective in VH or non-UC cancers, a rare histological subtype for which we currently have very little data in the literature. | |
dc.contributor.authoraffiliation | [Epaillard,N; Oudard,S; Thibault,C; Auclin E] Medical Oncology Department, Hôpital Européen Georges Pompidou, AP-HP, Université de Paris, Paris, France. [Parent,P; Loriot,Y; Lavaud,P] Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, Villejuif, France. [Vera-Cea,E-B; Rodriguez-Vida,A] Medical Oncology Department, Hospital del Mar, IMIM Research Institute, Barcelona, Spain. [Martinez-Chanza,N] Medical Oncology Departments, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium. [Dumont,C] Medical Oncology Department, Hôpital Saint Louis, AP-HP, Université de Paris, Paris, France. [Lozano,R] Prostate Cancer Clinical Research Unit, Spanish National Cancer Research Centre, Madrid, Spain. [Lozano,R; Llácer,C] Genitourinary Oncology Translational Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Ratta,R] Medical Oncology Department, Hopital Foch, Suresnes, France. | |