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dc.contributor.author | García-Marchena, Nuria | |
dc.contributor.author | Pizarro, Nieves | |
dc.contributor.author | Pavón, Francisco-Javier | |
dc.contributor.author | Martínez-Huélamo, Miriam | |
dc.contributor.author | Flores-López, María | |
dc.contributor.author | Requena-Ocaña, Nerea | |
dc.contributor.author | Araos, Pedro | |
dc.contributor.author | Silva-Peña, Daniel | |
dc.contributor.author | Suárez, Juan | |
dc.contributor.author | Santín, Luis J | |
dc.contributor.author | de la Torre, Rafael | |
dc.contributor.author | Rodríguez de Fonseca, Fernando | |
dc.contributor.author | Serrano, Antonia | |
dc.date.accessioned | 2024-02-12T19:47:36Z | |
dc.date.available | 2024-02-12T19:47:36Z | |
dc.date.issued | 2020-10-13 | |
dc.identifier.other | http://hdl.handle.net/10668/16413 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/18134 | |
dc.description.abstract | Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantified and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment. | |
dc.language.iso | eng | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Alcoholism | |
dc.subject.mesh | Biomarkers | |
dc.subject.mesh | Brain-Derived Neurotrophic Factor | |
dc.subject.mesh | Cognitive Dysfunction | |
dc.subject.mesh | Ethanol | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Insulin-Like Growth Factor I | |
dc.subject.mesh | Insulin-Like Growth Factor II | |
dc.subject.mesh | Lysophospholipids | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Neurotrophin 3 | |
dc.subject.mesh | Outpatients | |
dc.subject.mesh | Plasma | |
dc.subject.mesh | Young Adult | |
dc.title | Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients. | |
dc.type | research article | |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 33051508 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 17163 | es_ES |
dc.identifier.doi | 10.1038/s41598-020-74155-0 | |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.rights.accessRights | open access | es_ES |
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