dc.contributor.author | Navarro, Juan A | |
dc.contributor.author | Decara, Juan | |
dc.contributor.author | Medina-Vera, Dina | |
dc.contributor.author | Tovar, Rubén | |
dc.contributor.author | Suarez, Juan|Pavón, Francisco-Javier | |
dc.contributor.author | Serrano, Antonia | |
dc.contributor.author | Vida, Margarita | |
dc.contributor.author | Gutierrez-Adan, Alfonso | |
dc.contributor.author | Sanjuan, Carlos | |
dc.contributor.author | Baixeras, Elena | |
dc.contributor.author | Fonseca, Fernando Rodríguez de | |
dc.date.accessioned | 2024-02-12T19:46:39Z | |
dc.date.available | 2024-02-12T19:46:39Z | |
dc.date.issued | 2020-07-08 | |
dc.identifier.other | http://hdl.handle.net/10668/15920 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/18074 | |
dc.description.abstract | To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control. | |
dc.language.iso | eng | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | AKT | |
dc.subject | D-Pinitol | |
dc.subject | Ghrelin | |
dc.subject | Insulin | |
dc.subject | Insulin resistance | |
dc.subject | Liver | |
dc.subject | Phosphorylation | |
dc.subject.mesh | Administration, Oral | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Depression, Chemical | |
dc.subject.mesh | Fabaceae | |
dc.subject.mesh | Ghrelin | |
dc.subject.mesh | Glucagon | |
dc.subject.mesh | Glycogen | |
dc.subject.mesh | Glycogen Synthase Kinase 3 | |
dc.subject.mesh | Glycolysis | |
dc.subject.mesh | Inositol | |
dc.subject.mesh | Insulin Secretion | |
dc.subject.mesh | Liver | |
dc.subject.mesh | Male | |
dc.subject.mesh | Phosphorylation | |
dc.subject.mesh | Proto-Oncogene Proteins c-akt | |
dc.subject.mesh | Pyruvate Kinase | |
dc.subject.mesh | Rats, Wistar | |
dc.title | D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. | |
dc.type | research article | |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 32650579 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.number | 7 | es_ES |
dc.identifier.doi | 10.3390/nu12072030 | |
dc.identifier.e-issn | 2072-6643 | es_ES |
dc.identifier.journal | Nutrients | es_ES |
dc.rights.accessRights | open access | es_ES |