Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17490
Título
High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity
Autor(es)
Perez-Garcia, Felipe ISCIII | Martin-Vicente, Maria ISCIII | Rojas-García, Rosa Lía | Castilla-García, Lucía | Muñoz-Gómez, María José ISCIII | Hervás Fernández, Irene | González Ventosa, Victoria | Vidal-Alcántara, Erick Joan ISCIII | Cuadros-González, Juan | Bermejo-Martin, Jesús F | Resino, Salvador ISCIII | Martinez, Isidoro ISCIII
Fecha de publicación
2022-03-15
Cita
J Infect Dis. 2022 Mar 15;225(6):977-982.
Idioma
Inglés
Tipo de documento
research article
Resumen
Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity.
Palabras clave
CCL5 | COVID-19 | ICU | SARS-CoV-2 | Death | Gene expression | Innate immunity | Nasopharynx | Viral load
MESH
COVID-19 | SARS-CoV-2 | Chemokine CCL5 | Humans | Intensive Care Units | Nasopharynx | RNA, Viral | Severity of Illness Index | Viral Load
Versión en línea
DOI
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