Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17446
Título
High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
Autor(es)
Berenguer, Juan | Fernandez-Rodriguez, Amanda ISCIII | Jimenez-Sousa, Maria Angeles ISCIII | Cosín, Jaime | Zarate, Paola | Micheloud, Dariela | López, Juan Carlos | Miralles, Pilar | Catalán, Pilar | Resino, Salvador ISCIII
Fecha de publicación
2012-01
Cita
Cytokine. 2012 Jan;57(1):25-9.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: CXCL10 may contribute to the host immune response against the hepatitis C virus (HCV), liver disease progression, and response to HCV antiviral therapy. The aim of our study was to analyze the relationship among virological, immunological, and clinical characteristics with plasma CXCL10 levels in human immunodeficiency virus (HIV)/HCV-coinfected patients. Methods: We carried out a cross-sectional study on 144 patients. CXCL10 and insulin were measured using an immunoassay kit. The degree of insulin resistance was estimated for each patient using the homeostatic model assessment (HOMA) method. Insulin resistance was defined as a HOMA index higher than or equal to 3.8. Aspartate aminotransferase (AST) to platelet ratio (APRI), FIB-4, Forns index, HGM1, and HGM2 were calculated. Results: The variables associated with log(10) CXCL10 levels by univariate analysis were age (b=0.013; p=0.023), prior AIDS-defining condition (b=0.127; p=0.045), detectable plasma HIV viral load (b=0.092; p=0.006), log(10) HOMA (b=0.216; p=0.002), HCV-genotype 1 (b=0.114; p=0.071), and liver fibrosis assessed by all non-invasive indexes (log(10) APRI (b=0.296; p=0.001), log(10) FIB-4 (b=0.436; p<0.001), log(10) Forns index (b=0.591; p<0.001), log(10) HGM1 (b=0.351; p=0.021), and log(10) HGM2 (b=0.215; p=0.018)). However, in multivariate analysis, CXCL10 levels were only associated with HOMA, detectable plasma HIV viral load, HCV-genotype 1 and FIB-4 (R-square=0.235; p<0.001). Conclusion: Plasma CXCL10 levels were influenced by several characteristics of patients related to HIV and HCV infections, insulin resistance, and liver fibrosis, indicating that CXCL10 may play an important role in the pathogenesis of both HCV and HIV infections.
Palabras clave
MESH
Insulin Resistance | Adult | Antiviral Agents | Biomarkers | Chemokine CXCL10 | Coinfection | Disease Progression | Female | Genotype | HIV | Hepacivirus | Hepatitis C | Humans | Liver Cirrhosis | Male | Multivariate Analysis | Viral Load
Versión en línea
DOI
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