Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17413
Título
B Lymphocyte commitment program is driven by the proto-oncogene c-Myc.
Autor(es)
Fecha de publicación
2011-06-15
Cita
J Immunol . 2011;186(12):6726-36
Idioma
Inglés
Tipo de documento
journal article
Resumen
c-Myc, a member of the Myc family of transcription factors, is involved in numerous biological functions including the regulation of cell proliferation, differentiation, and apoptosis in various cell types. Of all of its functions, the role of c-Myc in cell differentiation is one of the least understood. We addressed the role of c-Myc in B lymphocyte differentiation. We found that c-Myc is essential from early stages of B lymphocyte differentiation in vivo and regulates this process by providing B cell identity via direct transcriptional regulation of the ebf-1 gene. Our data show that c-Myc influences early B lymphocyte differentiation by promoting activation of B cell identity genes, thus linking this transcription factor to the EBF-1/Pax-5 pathway.
MESH
Animals | B-Lymphocytes | Cell Differentiation | Gene Expression Regulation | Mice | PAX5 Transcription Factor | Proto-Oncogene Mas | Proto-Oncogene Proteins c-myc | Signal Transduction | Trans-Activators | Transcription Factors | Transcription, Genetic
Descripción
We thank I. Antón, C. Cobaleda, D. Martinez, and L. Torroja for a critical reading of the manuscript, M.A.R. Marcos for his input, M. Busslinger for ikneo mice, M. Reth for mb1-cre mice, H. Singh for EBF-MIG vectors, the Centro Nacional de Biotecnología animal facility and the Departamento de Inmunología y Oncología and Centro Nacional de Investigaciones Oncológicas FACS facility for help, and C. Mark for editorial assistance. Biotin–anti-NK1.1 Ab was a gift from C. Ardavín. This article is dedicated to the memory of M.A.R. Marcos.
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