Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/17402
Title
Role of Trypanosoma cruzi autoreactive T cells in the generation of cardiac pathology.
Author(s)
Date issued
2007-06
Citation
Ann N Y Acad Sci. 2007 Jun:1107:434-44.
Language
Inglés
Document type
journal article
Abstract
Chagas disease, caused by Trypanosoma cruzi, affects several million people in Central and South America. About 30% of chronic patients develop cardiomyopathy probably caused by parasite persistence and/or autoimmunity. While several cross-reactive antibodies generated during mammal T. cruzi infection have been described, very few cross-reactive T cells have been identified. We performed adoptive transfer experiments of T cells isolated from chronically infected mice. The results showed the generation of cardiac pathology in the absence of parasites. We also transferred cross-reactive SAPA-specific T cells and observed unspecific alterations in heart repolarization, cardiac inflammatory infiltration, and tissue damage.
MESH
Animals | Autoimmunity | Chagas Disease | Epitopes | Humans | Molecular Mimicry | T-Lymphocytes | Trypanosoma cruzi
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DOI
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