Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17238
Título
Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery
Autor(es)
Jimenez-Sousa, Maria Angeles ISCIII | Tamayo, Eduardo | Guzman-Fulgencio, Maria ISCIII | Heredia, María | Fernandez-Rodriguez, Amanda ISCIII | Gómez, Esther | Almansa, Raquel | Gómez-Herreras, José I | Garcia-Alvarez, Monica ISCIII | Gutiérrez-Junco, Sandra | Bermejo-Martin, Jesús F | Resino, Salvador ISCIII | Spanish Sepsis Group (SpSG)
Fecha de publicación
2015-01
Cita
J Infect. 2015 Jan;70(1):20-9.
Idioma
Inglés
Tipo de documento
research article
Resumen
Objective: To analyse whether mitochondrial DNA (mtDNA) haplogroups are associated with severe sepsis and mortality after major surgery. Methods: We performed a case-control study on 240 cardiac or abdominal surgery patients developing severe sepsis (Case-group) and 267 cardiac or abdominal surgery patients without severe sepsis and with systemic inflammatory response syndrome (SIRS, Control-group). Furthermore, a longitudinal substudy was performed for analysing the survival in septic patients. Only European white patients within the N macro-cluster were included. Results: Case-group underwent cardiac surgery had lower frequencies of cluster HV (p = 0.005) and haplogroup H (p = 0.005) and higher frequencies of cluster JT (p = 0.028) than Control-group; but no significant differences were found for abdominal surgery. Besides, both cluster HV and haplogroup H were associated with decreased odds of severe sepsis (adjusted odds ratio (aOR) = 0.45 (95%CI = 0.25; 0.82); p = 0.009 and aOR = 0.48 (95%CI = 0.26; 0.87); p = 0.015, respectively) among patients underwent cardiac surgery. In Case-group, 45.4% (109/240) patients died with a survival median of 39 (95%CI = 31.4; 46.62) days. When the clusters were examined, 41% (55/134) patients within cluster HV died versus 71.4% (10/14) patients within cluster IWX (p = 0.018). Additionally, patients within cluster IWX had an increased risk of death (adjusted hazard ratio (aHR) = 2.22; (95%CI = 1.14; 4.34); p = 0.019). Conclusions: European mitochondrial haplogroups might be related to the onset of severe sepsis in patients who underwent major cardiac surgery, but not in patients underwent major abdominal surgery. Besides, mtDNA haplogroups could have influence on mortality in septic patients.
Palabras clave
Mitochondrial haplogroups | mtDNA | Genetic polymorphism | Severe sepsis | Systemic inflammatory response syndrome (SIRS) | Survival
MESH
APACHE | Abdomen | Aged | Aged, 80 and over | Cardiovascular Surgical Procedures | Case-Control Studies | DNA, Mitochondrial | Female | General Surgery | Genotype | Haplotypes | Humans | Logistic Models | Male | Medical Records | Middle Aged | Sepsis | Spain | Survival Rate | Systemic Inflammatory Response Syndrome | White People
Versión en línea
DOI
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