Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17044
Título
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Autor(es)
Palacín, Arantxa | Gómez-Casado, Cristina | Rivas, Luis A | Aguirre, Jacobo | Tordesillas, Leticia | Bartra, Joan | | Carrillo, Teresa | Cuesta-Herranz, Javier | Frutos, Consolación de | García Alvarez-Eire, Genoveva | Fernández, Francisco J | Gamboa, Pedro | Muñoz, Rosa | Sánchez-Monge, Rosa | Sirvent, Sofía | Torres, María J | Varela-Losada, Susana | Rodríguez, Rosalía | Parro, Victor | Blanca, Miguel | Salcedo, Gabriel | Díaz-Perales, Araceli
Fecha de publicación
2012-12-14
Idioma
Inglés
Tipo de documento
research article
Resumen
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
Palabras clave
Reacciones Cruzadas | Estudios multicéntricos como asunto | Hipersensibilidad | Análisis de micromatrices | Inmunoanálisis | España
MESH
Cross Reactions | Carrier Proteins | Plant Proteins | Antigens, Plant | Multicenter Studies as Topic | Hypersensitivity | Microarray Analysis | Immunoassay | Fruit | Plants | Spain | Pollen
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > IIS > IBIMA-Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (Andalucía)
- Investigación > IIS > IIS-PRINCESA - Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (Madrid)
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