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dc.contributor.author | Yoon, Jeonggyo | |
dc.contributor.author | García-Esquinas, Esther | |
dc.contributor.author | Kim, Junghoon | |
dc.contributor.author | Kwak, Jung Hyun | |
dc.contributor.author | Kim, Hongsoo | |
dc.contributor.author | Kim, Sungroul | |
dc.contributor.author | Kim, Kyoung-Nam | |
dc.contributor.author | Hong, Yun-Chul | |
dc.contributor.author | Choi, Yoon-Hyeong | |
dc.date.accessioned | 2024-01-09T11:43:04Z | |
dc.date.available | 2024-01-09T11:43:04Z | |
dc.date.issued | 2023-04 | |
dc.identifier.citation | Environ Health Perspect. 2023 Apr;131(4):47005. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16906 | |
dc.description.abstract | Background: Previous epidemiological studies have suggested that phthalate exposure may contribute to neurocognitive and neurobehavioral disorders and decreased muscle strength and bone mass, all of which may be associated with reduced physical performance. Walking speed is a reliable assessment tool for measuring physical performance in adults age 60 y and older. Objective: We investigated associations between urinary phthalate metabolites and slowness of walking speed in community-dwelling adults ages 60-98 y. Methods: We analyzed 1,190 older adults [range, 60-98 y of age; mean ± standard deviation (SD), 74.81 ± 5.99] from the Korean Elderly Environmental Panel II study and measured repeatedly up to three times between 2012 and 2014. Phthalate exposure was estimated using the following phthalate metabolites in urine samples: mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-n-butyl phthalate (MnBP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP). Slowness was defined as a walking speed of < 1.0 meter/second. We used logistic and linear regression models to evaluate the association between each urinary phthalate metabolite and slowness or walking-speed change. We also used Bayesian kernel machine regression (BKMR) to examine overall mixture effects on walking speed. Results: At enrollment, MBzP levels were associated with an increased odds of slowness [odds ratio (OR) per doubling increase: 1.15, 95% confidence interval (CI): 1.02, 1.30; OR for the highest vs. lowest quartile: 2.20 (95% CI: 1.12, 4.35) with p-trend across quartiles = 0.031]. In longitudinal analyses, MEHHP levels showed an increased risk of slowness [OR per doubling increase: 1.15 (95% CI: 1.02, 1.29), OR for the highest vs. lowest quartile: 1.47 (95% CI: 1.04, 2.06), p−trend=0.035]; whereas those with higher MnBP showed a reduced risk of slowness [OR per doubling increase: 0.84 (95% CI: 0.74, 0.96), OR in the highest (vs. lowest) quartile: 0.64 (95% CI: 0.47, 0.87), p−trend=0.006]. For linear regression models, MBzP quartiles were associated with slower walking speed (p−trend=0.048) at enrollment, whereas MEHHP quartiles were associated with slower walking speed, and MnBP quartiles were associated with faster walking speed in longitudinal analysis (p−trend=0.026 and <0.001, respectively). Further, the BKMR analysis revealed negative overall trends between the phthalate metabolite mixtures and walking speed and DEHP group (MEHHP, MEOHP, and MECPP) had the main effect of the overall mixture. Discussion: Urinary concentrations of prevalent phthalates exhibited significant associations with slow walking speed in adults ages 60-98 y. https://doi.org/10.1289/EHP10549. | es_ES |
dc.description.sponsorship | This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Korea Ministry of Education and the Korea Ministry of Science and Information and Communication Technology (grant numbers 2013R1A6A3A04059556; 2020R1A2C110170311). Also, this study was supported by the Susceptible Population Research Program (2008–2010) from the Korea Ministry of Environment (grant numbers 0411-20080013, 0411-20090007, 0411-20100016). E.G.-E. was supported by the Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) (ESP21PI04/2021). The funders had no role in this study design, data collection, and analysis and prepared all results. All authors participated in literature search and data interpretation. Y.C. supervised the study; Y.C. and Y.H. participated in designing the study; H.K., S.K., and K.K. acquired the data; J.Y., J. Kim, and J. Kwak analyzed data; J.Y. wrote the manuscript; E.G.-E., J. Kim, J. Kwak, H.K., Y.H., and Y.C. critically revised the manuscript. Patient consent was obtained. This study was approved by the institutional review board (IRB) of Seoul National University Hospital/College of Medicine (IRB No. H-1209-004-424). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | National Institute of Environmental Health Sciences (NIEHS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Environmental Pollutants | es_ES |
dc.subject.mesh | Phthalic Acids | es_ES |
dc.subject.mesh | Diethylhexyl Phthalate | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Aged, 80 and over | es_ES |
dc.subject.mesh | Environmental Exposure | es_ES |
dc.subject.mesh | Bayes Theorem | es_ES |
dc.subject.mesh | Walking Speed | es_ES |
dc.subject.mesh | Republic of Korea | es_ES |
dc.title | Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 37018009 | es_ES |
dc.format.volume | 131 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 47005 | es_ES |
dc.identifier.doi | 10.1289/EHP10549 | es_ES |
dc.contributor.funder | National Research Foundation of Korea | es_ES |
dc.contributor.funder | Ministry of Science, ICT and Future Planning (Korea) | es_ES |
dc.contributor.funder | Ministry of Education (Korea) | es_ES |
dc.contributor.funder | Ministry of Environment (Korea) | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública) | es_ES |
dc.contributor.funder | Seoul National University Hospital (Korea) | es_ES |
dc.contributor.funder | Seoul National University (Korea) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1552-9924 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1289/EHP10549 | es_ES |
dc.identifier.journal | Environmental health perspectives | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |