Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16894
Título
Monitoring COVID-19 vaccine effectiveness against COVID-19 hospitalisation and death using electronic health registries in ≥65 years old population in six European countries, October 2021 to November 2022
Autor(es)
Kislaya, Irina | Sentís, Alexis | Starrfelt, Jostein | Nunes, Baltazar | Martínez-Baz, Iván | Nielsen, Katrine Finderup | AlKerwi, Ala'a | Braeye, Toon | Fontán-Vela, Mario ISCIII | Bacci, Sabrina | Meijerink, Hinta | Castilla, Jesús | Emborg, Hanne-Dorthe | Hansen, Christian Holm | Schmitz, Susanne | Van Evercooren, Izaak | Valenciano, Marta | Nardone, Anthony | Nicolay, Nathalie | Monge Corella, Susana ISCIII | VEBIS-Lot4 working group
Fecha de publicación
2023-11
Cita
Influenza Other Respir Viruses. 2023 Nov;17(11):e13195.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: Within the ECDC-VEBIS project, we prospectively monitored vaccine effectiveness (VE) against COVID-19 hospitalisation and COVID-19-related death using electronic health registries (EHR), between October 2021 and November 2022, in community-dwelling residents aged 65-79 and ≥80 years in six European countries. Methods: EHR linkage was used to construct population cohorts in Belgium, Denmark, Luxembourg, Navarre (Spain), Norway and Portugal. Using a common protocol, for each outcome, VE was estimated monthly over 8-week follow-up periods, allowing 1 month-lag for data consolidation. Cox proportional-hazards models were used to estimate adjusted hazard ratios (aHR) and VE = (1 - aHR) × 100%. Site-specific estimates were pooled using random-effects meta-analysis. Results: For ≥80 years, considering unvaccinated as the reference, VE against COVID-19 hospitalisation decreased from 66.9% (95% CI: 60.1; 72.6) to 36.1% (95% CI: -27.3; 67.9) for the primary vaccination and from 95.6% (95% CI: 88.0; 98.4) to 67.7% (95% CI: 45.9; 80.8) for the first booster. Similar trends were observed for 65-79 years. The second booster VE against hospitalisation ranged between 82.0% (95% CI: 75.9; 87.0) and 83.9% (95% CI: 77.7; 88.4) for the ≥80 years and between 39.3% (95% CI: -3.9; 64.5) and 80.6% (95% CI: 67.2; 88.5) for 65-79 years. The first booster VE against COVID-19-related death declined over time for both age groups, while the second booster VE against death remained above 80% for the ≥80 years. Conclusions: Successive vaccine boosters played a relevant role in maintaining protection against COVID-19 hospitalisation and death, in the context of decreasing VE over time. Multicountry data from EHR facilitate robust near-real-time VE monitoring in the EU/EEA and support public health decision-making.
Palabras clave
COVID-19 | COVID-19-related death | SARS-CoV-2 | Cohort design | Hospitalization | Vaccine effectiveness
MESH
COVID-19 Vaccines | COVID-19 | Humans | Aged | Vaccine Efficacy | Registries | Electronics | Hospitalization
Versión en línea
DOI
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