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dc.contributor.author | Suárez-García, I | |
dc.contributor.author | Gutierrez, Félix | |
dc.contributor.author | Pérez-Molina, José A | |
dc.contributor.author | Moreno, Santiago | |
dc.contributor.author | Aldamiz, Teresa | |
dc.contributor.author | Valencia Ortega, Eulalia | |
dc.contributor.author | Curran, Adrián | |
dc.contributor.author | Gutiérrez González, Sara | |
dc.contributor.author | Asensi, Víctor | |
dc.contributor.author | Amador Prous, Concha | |
dc.contributor.author | Jarrin-Vera, Inmaculada | |
dc.contributor.author | Rava, Marta | |
dc.contributor.author | CoRIS | |
dc.date.accessioned | 2023-12-05T09:05:47Z | |
dc.date.available | 2023-12-05T09:05:47Z | |
dc.date.issued | 2023-11-26 | |
dc.identifier.citation | J Cancer Res Clin Oncol. 2023 Nov 26. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16749 | |
dc.description.abstract | Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results: Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion: Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population. | es_ES |
dc.description.abstract | Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results: Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion: Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population. | |
dc.description.sponsorship | Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was supported by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB21/13/00091), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU, the Gilead Scholarship Program for Biomedical Research (GLD19_00106) and the ISCIII- Miguel Servet CP19CIII—00002 contract. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cancer | es_ES |
dc.subject | Mortality | es_ES |
dc.subject | HIV | es_ES |
dc.subject | Cohort study | es_ES |
dc.title | Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38008809 | es_ES |
dc.identifier.doi | 10.1007/s00432-023-05500-9 | es_ES |
dc.contributor.funder | Conferencia de Rectores de las Universidades Españolas | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. NextGenerationEU | es_ES |
dc.contributor.funder | Gilead Sciences (Spain) | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1432-1335 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1007/s00432-023-05500-9 | es_ES |
dc.identifier.journal | Journal of cancer research and clinical oncology | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/CB21/13/00091 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/CP19CIII-00002 | es_ES |
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ISPA - Instituto de Investigación Sanitaria del Principado de Asturias (Asturias)
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IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
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Centro Nacional de Epidemiología (CNE)
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IR-HUVH - Instituto de Investigación Hospital Universitari Vall d’Hebron (Cataluña)
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IRYCIS - Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)