Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16731
Título
Factors related to the development of high antibody titres against SARS-CoV-2 in convalescent plasma donors from the ConPlas-19 trial
Autor(es)
Romera Martínez, Irene | Avendaño-Solá, Cristina | Villegas Da Ros, Carolina | Bosch Llobet, Alba | García Erce, José Antonio | González Fraile, María Isabel | Guerra Domínguez, Luisa | Vicuña Andrés, Isabel | Anguita Velasco, Javier | González Rodríguez, Victoria Paz | Contreras, Enric | Urcelay Uranga, Sabin | Pajares Herraiz, Ángel Luis | Jimenez-Marco, Teresa | Ojea Pérez, Ana María | Arroyo Rodríguez, José Luis | Perez-Olmeda, Mayte ISCIII | Ramos-Martínez, Antonio | Velasco-Iglesias, Ana | Bueno Cabrera, José Luis | Duarte, Rafael F
Fecha de publicación
2024
Cita
Vox Sang. 2024 Jan;119(1):27-33.
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Inglés
Tipo de documento
research article
Resumen
Background and objectives: The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas-19 donors and characteristics that associate with high anti-SARS-CoV-2 antibody levels. Materials and methods: Four-hundred donors were enrolled in ConPlas-19. The presence and titres of anti-SARS-CoV-2 antibodies were evaluated by EUROIMMUN anti-SARS-CoV-2 S1 IgG ELISA. Results: A majority of 80.3% of ConPlas-19 donor candidates had positive EUROIMMUN test results (ratio ≥1.1), and of these, 51.4% had high antibody titres (ratio ≥3.5). Antibody levels decline over time, but nevertheless, out of 37 donors tested for an intended second CP donation, over 90% were still EUROIMMUN positive, and nearly 75% of those with high titres maintained high titres in the second sample. Donors with a greater probability of developing high titres of anti-SARS-CoV-2 antibodies include those older than 40 years of age (RR 2.06; 95% CI 1.24-3.42), with more than 7 days of COVID-19 symptoms (RR 1.89; 95% CI 1.05-3.43) and collected within 4 months from infection (RR 2.61; 95% CI 1.16-5.90). Male donors had a trend towards higher titres compared with women (RR 1.67; 95% CI 0.91-3.06). Conclusion: SARS-CoV-2 CP candidate donors' age, duration of COVID-19 symptoms and time from infection to donation associate with the collection of CP with high antibody levels. Beyond COVID-19, these data are relevant to inform decisions to optimize the CP donor selection process in potential future outbreaks.
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