Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16667
Título
Bronchopulmonary penetration of isavuconazole in lung transplant recipients
Autor(es)
Fecha de publicación
2023-10-18
Cita
Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0061323.
Idioma
Inglés
Tipo de documento
research article
Resumen
Isavuconazole's (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung.
Palabras clave
Isavuconazole | Invasive fungal infection | Bronchoalveolar lavage | Tissue penetration | Lung transplant
MESH
Versión en línea
DOI
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- Nombre:
- BronchopulmonaryPenetrationIsa ...
- Tamaño:
- 2.710Mb
- Formato:
- Descripción:
- Articulo
- Nombre:
- Supplementary1_Bronchopulmonar ...
- Tamaño:
- 757.4Kb
- Formato:
- Descripción:
- Supplementary material 1
- Nombre:
- Supplementary2_Bronchopulmonar ...
- Tamaño:
- 413.0Kb
- Formato:
- Descripción:
- Supplementary material 2