Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16566
Título
ISG20L2: an RNA nuclease regulating T cell activation.
Autor(es)
Rodriguez-Galan, Ana CNIC | Dosil, Sara G | Hrčková, Anna | Fernandez-Messina, Lola CNIC | Feketová, Zuzana | Pokorná, Julie | Fernandez-Delgado, Irene CNIC | Camafeita, Emilio CNIC | Gómez, Manuel José | Ramírez-Huesca, Marta | Gutierrez-Vazquez, Cristina CNIC | Sanchez-Cabo, Fatima CNIC | Vazquez, Jesus CNIC | Vaňáčová, Štěpánka | Sánchez-Madrid, Francisco
Fecha de publicación
2023-08-30
Cita
Cell Mol Life Sci. 2023 Aug 30;80(9):273.
Idioma
Inglés
Tipo de documento
journal article
Resumen
ISG20L2, a 3' to 5' exoribonuclease previously associated with ribosome biogenesis, is identified here in activated T cells as an enzyme with a preferential affinity for uridylated miRNA substrates. This enzyme is upregulated in T lymphocytes upon TCR and IFN type I stimulation and appears to be involved in regulating T cell function. ISG20L2 silencing leads to an increased basal expression of CD69 and induces greater IL2 secretion. However, ISG20L2 absence impairs CD25 upregulation, CD3 synaptic accumulation and MTOC translocation towards the antigen-presenting cell during immune synapsis. Remarkably, ISG20L2 controls the expression of immunoregulatory molecules, such as AHR, NKG2D, CTLA-4, CD137, TIM-3, PD-L1 or PD-1, which show increased levels in ISG20L2 knockout T cells. The dysregulation observed in these key molecules for T cell responses support a role for this exonuclease as a novel RNA-based regulator of T cell function.
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- ISG20L2_Cell Mol Life Sci_2023.pdf
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