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dc.contributor.author | Juste, Ramón A | |
dc.contributor.author | Blanco-Vázquez, Cristina | |
dc.contributor.author | Barral, Marta | |
dc.contributor.author | Prieto, José Miguel | |
dc.contributor.author | Varela-Castro, Lucía | |
dc.contributor.author | Lesellier, Sandrine | |
dc.contributor.author | Dave, Dipesh | |
dc.contributor.author | Sevilla, Iker A | |
dc.contributor.author | Martín Ezquerra, Ana Belén | |
dc.contributor.author | Adriaensen, Hans | |
dc.contributor.author | Herrero-García, Gloria | |
dc.contributor.author | Garrido, Joseba M | |
dc.contributor.author | Casais, Rosa | |
dc.contributor.author | Balseiro, Ana | |
dc.date.accessioned | 2023-09-29T10:24:19Z | |
dc.date.available | 2023-09-29T10:24:19Z | |
dc.date.issued | 2023-09 | |
dc.identifier.citation | Heliyon. 2023 Aug 21;9(9):e19349. | es_ES |
dc.identifier.issn | 2405-8440 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16534 | |
dc.description.abstract | Badgers (Meles meles) are a major tuberculosis (TB) reservoir in Europe, with the potential to transmit infection to cattle. Here we assessed whether a recently described oral tuberculosis vaccine based on heat-inactivated Mycobacterium bovis (HIMB), delivered as edible baits, can protect badgers from infection. Eight badgers were given individually five baits, each one consisting of a ball of peanut butter, natural peanut and oat flakes including a dose of the vaccine containing 5 × 107 colony-forming units. In parallel, a control group of seven badgers did not receive the vaccine. One month and a half later a second dose of the vaccine was offered to the vaccinated group. Ninety-four days after the second dose, all badgers were challenged with M. bovis (103 colony-forming units per animal) delivered endobronchially to the right middle lung lobe. Clinical, immunological, pathological and bacteriological variables were measured throughout the whole study to assess the efficacy of the vaccine. Two vaccinated animals showed high bacterial load of M. bovis and worsening of pathological lesions of TB. Conversely, the other six vaccinated animals showed slight improvement in bacterial load and pathology with respect to the control group. These results suggest that delivering the TB vaccine via food bait can partially protect wild badger populations, although vaccination can lead to either protection or tolerization, likely depending on the animal's immune status and general condition at the time of vaccination. Further optimization of the vaccination trial/strategy is needed to reduce the rate of tolerization, such as altering vaccine dose, number of doses, type of bait, use of adjuvants or route of administration. | es_ES |
dc.description.sponsorship | This work is result of the I+D+i research project RTI2018-096010-B-C21, funded by the Spanish MCIN/AEI/10.13039/501100011033/Ministry of Science, Innovation and the European Regional Development Funds (FEDER Una manera de hacer Europa). This work was also partially funded by the Principality of Asturias, PCTI 2021–2023 (GRUPIN: IDI-2021-000102) and European Regional Development Fund. The cost of the running MRI was financed by the European Commission in the context of Horizon 2020 – Vetbionet Transnational Access Activities (TNA) call. DEFRA also funded APHA staff for their participation in the study. Dr. Cristina Blanco Vázquez was granted with a predoctoral fellowship CPD2016-0142 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”. Gloria Herrero-García was granted with a predoctoral fellowship by Junta de Castilla y León and FSE (LE036-20). All methods were carried out in accordance with relevant guidelines and regulations. All experimental protocols were approved by the Animal Ethics Committees of the Government of the Principality of Asturias (license PROAE 47/2018) and the Diputación Foral de Bizkaia (license 201944). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Badger | es_ES |
dc.subject | Efficacy | es_ES |
dc.subject | HIMB | es_ES |
dc.subject | Mycobacterium bovis heat-inactivated bait oral vaccine | es_ES |
dc.subject | Tuberculosis | es_ES |
dc.title | Efficacy of heat-inactivated Mycobacterium bovis vaccine delivered to European badgers (Meles meles) through edible bait | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 37662827 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | e19349 | es_ES |
dc.identifier.doi | 10.1016/j.heliyon.2023.e19349 | es_ES |
dc.contributor.funder | Plan Nacional de I+D+i (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Gobierno del Principado de Asturias (España) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Junta de Castilla y León (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.heliyon.2023.e19349 | es_ES |
dc.identifier.journal | Heliyon | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-096010-B-C21 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CPD2016-0142 | es_ES |