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dc.contributor.authorMazagatos, Clara 
dc.contributor.authorDelgado-Sanz, Concepcion 
dc.contributor.authorMilagro, Ana
dc.contributor.authorLiébana-Rodríguez, María
dc.contributor.authorLarrauri, Amparo
dc.identifier.citationVaccines (Basel). 2023 Jun 17;11(6):1110.es_ES
dc.description.abstractAnnual influenza vaccination is the main strategy to reduce the burden of seasonal influenza epidemics and is recommended for the elderly in most countries with influenza vaccination strategies, with the main objective of preventing hospitalizations and mortality associated with seasonal influenza in this age group. Studies from different countries have estimated the benefits of seasonal influenza vaccination programs in the elderly, preventing a considerable number of cases, hospitalizations and deaths every year. A study measured the number of medically attended confirmed influenza cases in primary care that are prevented annually by vaccination in the population aged 65 and older in Spain, the Netherlands and Portugal, but estimates of the impact of the national influenza vaccination program in the prevention of severe disease in Spain are lacking. The two objectives of this study were to estimate the burden of severe influenza disease in the Spanish population and to measure the impact of influenza vaccination in the prevention of these outcomes in the population aged 65 years and older. Using influenza surveillance systems put in place before the COVID-19 pandemic, we conducted a retrospective observational study to estimate the burden of hospitalizations and ICU admissions in Spain between 2017-18 and 2019-20, by season and age group. Burden estimates for the 65+ group, combined with vaccine effectiveness (VE) and vaccination coverage (VC) data, were used as input data in an ecological, observational study to estimate the impact of the influenza vaccination program on the elderly. We found a higher burden of severe influenza disease in seasons 2017-18 and 2018-19, with A(H3N2) circulation, and in the youngest and oldest age groups. In those aged 65 and older, we estimated an average of 9900 influenza hospitalizations and 1541 ICU admissions averted by vaccination each year. Seasonal influenza vaccination was able to prevent between 11 and 26% influenza hospitalizations and around 40% ICU admissions in the elderly in the three pre-pandemic seasons. In conclusion, our study complements previous analyses in the primary care setting in Spain and demonstrates the benefits of the annual influenza vaccination program in the prevention of severe influenza disease in the elderly, even in seasons with moderate VE.es_ES
dc.description.sponsorshipActivities related to vaccine effectiveness and impact studies in individuals aged 65 and older were supported by the European Commission HORIZON 2020 program, grant No 634446. The funding body had no role in the design, collection, analysis, interpretation of data or in the writing of this manuscript. CM received a travel grant from CIBERESP (CIBER Epidemiología y Salud Pública) in 2019 to cover a 3-month visit as guest researcher to the CDC in Atlanta (United States), where she worked on this paper to complete her PhD with international mention.es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.titleImpact of Influenza Vaccination on the Burden of Severe Influenza in the Elderly: Spain, 2017-2020es_ES
dc.typeresearch articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea. H2020 es_ES
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública) es_ES
dc.contributor.funderCenters for Disease Control and Prevention (Estado Unidos) es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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