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dc.contributor.authorFabre-Estremera, Blanca
dc.contributor.authorBuño-Soto, Antonio
dc.contributor.authorGarcía-Esquinas, Esther 
dc.contributor.authorCabanas-Sánchez, Verónica
dc.contributor.authorMartínez-Gómez, David
dc.contributor.authorRodríguez-Artalejo, Fernando
dc.contributor.authorOrtolá, Rosario
dc.identifier.citationEur Rev Aging Phys Act. 2023 Mar 9;20(1):5.es_ES
dc.description.abstractBackground: High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are biomarkers of myocardial infarction and heart failure, respectively, and indicate cardiovascular risk. Since low physical activity (PA) and sedentary behavior (SB) are also associated with higher cardiovascular risk, and this association could be a consequence of higher levels of cardiac biomarkers, we examined the association of device-measured movement behaviors with hs-cTnT and NT-proBNP in older men and women without major cardiovascular disease (CVD). Methods: We used data from 1939 older adults from the Seniors-ENRICA-2 study. Accelerometers were used to assess time spent in sleep, SB, light PA (LPA), and moderate-to-vigorous PA (MVPA). Linear regression models were fitted separately in eight strata defined by sex, by median total PA time, and by the presence of subclinical cardiac damage according to cardiac biomarkers levels. Results: In the less active men with subclinical cardiac damage, spending 30 min/day more of MVPA was associated with a mean percentage difference (MPD) (95% confidence interval) in hs-cTnT of - 13.1 (- 18.3, - 7.5); MPDs in NT-proBNP per 30 min/day increment were 5.8 (2.7, 8.9) for SB, - 19.3 (- 25.4, - 12.7) for LPA and - 23.1 (- 30.7, - 14.6) for MVPA. In women with subclinical cardiac damage who were less physically active, 30 min/day more of SB, LPA and MVPA were associated with MPDs in hs-cTnT of 2.1 (0.7, 3.6), - 5.1 (- 8.3, - 1.7) and - 17.5 (- 22.9, - 11.7), respectively, whereas in those more active, LPA and MVPA were associated with MPDs of 4.1 (1.2, 7.2) and - 5.4 (- 8.7, - 2.0), respectively. No associations were found with NT-proBNP in women. Conclusions: The relationship between movement behaviors and cardiac biomarkers in older adults without major CVD depends on sex, subclinical cardiac damage and PA level. More PA and less SB were generally related to lower cardiac biomarkers levels among less active individuals with subclinical cardiac damage, with greater benefits for hs-cTnT in women than men and no benefits for NT-proBNP in women.es_ES
dc.description.sponsorshipThis work was supported by Instituto de Salud Carlos III, State Secretary of R+D+I and Fondo Europeo de Desarrollo Regional / Fondo Social Europeo (Fondo de Investigaciones Sanitarias grants 18/287, 19/319). DMG is supported by a Ramón y Cajal contract from the Ministry of Science, Innovation and Universities and Fondo Europeo de Desarrollo Regional / Fondo Social Europeo (RYC-2016-20546) and VCS by a Juan de la Cierva contract from the Ministry of Science, Innovation and Universities (IJC2018–038008-I). Reagents for measuring hs-cTnT and NT-proBNP have been provided by Roche Diagnostics International through a Research Agreement with the FUAM (Fundación de la Universidad Autónoma de Madrid). The funding agencies had no role in study design, data collection and analysis, interpretation of results, manuscript preparation or the decision to submit this manuscript for publication.es_ES
dc.publisherBioMed Central (BMC) es_ES
dc.subjectHigh-sensitivity cardiac troponin Tes_ES
dc.subjectPhysical activityes_ES
dc.subjectSedentary behaviores_ES
dc.subjectOlder adultses_ES
dc.titleDevice-measured movement behaviors and cardiac biomarkers in older adults without major cardiovascular disease: the Seniors-ENRICA-2 studyes_ES
dc.typeresearch articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) es_ES
dc.contributor.funderPlan Nacional de I+D+i (España) es_ES
dc.contributor.funderUnión Europea. Fondo Social Europeo (ESF/FSE) es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) es_ES
dc.contributor.funderRoche es_ES
dc.contributor.funderFundación de la Universidad Autónoma de Madrides_ES
dc.identifier.journalEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activityes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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