Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16393
Título
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value.
Autor(es)
Enríquez-Vázquez, Daniel | Quintanilla, Jorge G | García-Escolano, Alba | Couselo-Seijas, Marinela | Simón-Chica, Ana | Lee, Peter | Alfonso-Almazan, Jose M. CNIC | Mahía, Patricia | Redondo-Rodríguez, Andrés | Modrego, Javier | Ortega-Hernández, Adriana | Marcos-Alberca, Pedro | Magni, Ricardo CNIC | Calvo, Enrique CNIC | Gómez-Gordo, Rubén | Yan, Ping | La Rosa, Giulio | Bustamante-Madrión, José | Pérez-García, Carlos Nicolás | Martín-Sánchez, F Javier | Calvo, David | de la Hera, Jesús M | García-Torrent, María Jesús | García-Osuna, Álvaro | Ordonez-Llanos, Jordi | Vazquez, Jesus CNIC | Pérez-Villacastín, Julián | Pérez-Castellano, Nicasio | Loew, Leslie M | Sánchez-González, Javier | Gómez-Garre, Dulcenombre | Filgueiras-Rama, David CNIC
Fecha de publicación
2023-08-04
Cita
Nat Commun. 2023 Aug 4;14(1):4613.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. In pigs, sequential electromechanical assessment during AF progression shows a progressive decrease in mechanical activity and early dissociation from its electrical counterpart. Atrial tissue samples from animals with AF reveal an abnormal increase in cardiomyocytes death and alterations in calcium handling proteins. High-throughput quantitative proteomics and immunoblotting analyses at different stages of AF progression identify downregulation of contractile proteins and progressive increase in atrial fibrosis. Moreover, advanced optical mapping techniques, applied to whole heart preparations during AF, demonstrate that AF-related remodeling decreases the frequency threshold for dissociation between transmembrane voltage signals and intracellular calcium transients compared to healthy controls. Single cell simulations of human atrial cardiomyocytes also confirm the experimental results. In patients, non-invasive assessment of the atrial electromechanical relationship further demonstrate that atrial electromechanical dissociation is an early prognostic indicator for acute and long-term rhythm control.
MESH
Atrial Fibrillation | Atrial Remodeling | Muscular Diseases | Humans | Animals | Swine | Prognosis | Calcium | Heart Atria
Versión en línea
DOI
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