dc.contributor.author | Enríquez-Vázquez, Daniel | |
dc.contributor.author | Quintanilla, Jorge G | |
dc.contributor.author | García-Escolano, Alba | |
dc.contributor.author | Couselo-Seijas, Marinela | |
dc.contributor.author | Simón-Chica, Ana | |
dc.contributor.author | Lee, Peter | |
dc.contributor.author | Alfonso-Almazan, Jose M. | |
dc.contributor.author | Mahía, Patricia | |
dc.contributor.author | Redondo-Rodríguez, Andrés | |
dc.contributor.author | Modrego, Javier | |
dc.contributor.author | Ortega-Hernández, Adriana | |
dc.contributor.author | Marcos-Alberca, Pedro | |
dc.contributor.author | Magni, Ricardo | |
dc.contributor.author | Calvo, Enrique | |
dc.contributor.author | Gómez-Gordo, Rubén | |
dc.contributor.author | Yan, Ping | |
dc.contributor.author | La Rosa, Giulio | |
dc.contributor.author | Bustamante-Madrión, José | |
dc.contributor.author | Pérez-García, Carlos Nicolás | |
dc.contributor.author | Martín-Sánchez, F Javier | |
dc.contributor.author | Calvo, David | |
dc.contributor.author | de la Hera, Jesús M | |
dc.contributor.author | García-Torrent, María Jesús | |
dc.contributor.author | García-Osuna, Álvaro | |
dc.contributor.author | Ordonez-Llanos, Jordi | |
dc.contributor.author | Vazquez, Jesus | |
dc.contributor.author | Pérez-Villacastín, Julián | |
dc.contributor.author | Pérez-Castellano, Nicasio | |
dc.contributor.author | Loew, Leslie M | |
dc.contributor.author | Sánchez-González, Javier | |
dc.contributor.author | Gómez-Garre, Dulcenombre | |
dc.contributor.author | Filgueiras-Rama, David | |
dc.date.accessioned | 2023-09-04T10:35:45Z | |
dc.date.available | 2023-09-04T10:35:45Z | |
dc.date.issued | 2023-08-04 | |
dc.identifier.citation | Nat Commun. 2023 Aug 4;14(1):4613. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16393 | |
dc.description.abstract | Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. In pigs, sequential electromechanical assessment during AF progression shows a progressive decrease in mechanical activity and early dissociation from its electrical counterpart. Atrial tissue samples from animals with AF reveal an abnormal increase in cardiomyocytes death and alterations in calcium handling proteins. High-throughput quantitative proteomics and immunoblotting analyses at different stages of AF progression identify downregulation of contractile proteins and progressive increase in atrial fibrosis. Moreover, advanced optical mapping techniques, applied to whole heart preparations during AF, demonstrate that AF-related remodeling decreases the frequency threshold for dissociation between transmembrane voltage signals and intracellular calcium transients compared to healthy controls. Single cell simulations of human atrial cardiomyocytes also confirm the experimental results. In patients, non-invasive assessment of the atrial electromechanical relationship further demonstrate that atrial electromechanical dissociation is an early prognostic indicator for acute and long-term rhythm control. | es_ES |
dc.description.sponsorship | This work was supported by the European Union Horizon 2020 research
and innovation program under Grant Agreement#965286. The study was
also supported by the Ministry of Science and Innovation (MCIN) (PID2019-
109329RB-I00 and PGC2018-097019-B-I00) funded by MCIN / AEI /
10.13039/501100011033, the Instituto de Salud Carlos III (Fondo de
Investigación Sanitaria grant PRB3) (PT17/0019/0003- ISCIII-SGEFI / ERDF,
ProteoRed), the Fundación Interhospitalaria para la Investigación Cardiovascular, the Fundación Salud 2000 and by “la Caixa” Banking Foundation
(project code HR17-00247). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Instituto de Salud Carlos III
(ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC
Foundation, and is a Severo Ochoa Center of Excellence (CEX2020-
001041-S funded by MICIN/AEI/10.13039/501100011033). We also thank
Asunción Conde and Sergey Mironov for their support on monitoring
database quality and advice in ECG signal processing, respectively. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Atrial Fibrillation | es_ES |
dc.subject.mesh | Atrial Remodeling | es_ES |
dc.subject.mesh | Muscular Diseases | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Swine | es_ES |
dc.subject.mesh | Prognosis | es_ES |
dc.subject.mesh | Calcium | es_ES |
dc.subject.mesh | Heart Atria | es_ES |
dc.title | Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 37542075 | es_ES |
dc.format.volume | 14 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 4613 | es_ES |
dc.identifier.doi | 10.1038/s41467-023-40196-y | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. Horizonte Europa | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Fundación Interhospitalaria de Investigación Cardiovascular | es_ES |
dc.contributor.funder | Fundación Salud 2000 | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2041-1723 | es_ES |
dc.relation.publisherversion | 10.1038/s41467-023-40196-y | es_ES |
dc.identifier.journal | Nature communications | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-109329RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PGC2018-097019-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PT17/0019/0003 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17-00247 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MICIN/AEI/10.13039/501100011033 | es_ES |