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dc.contributor.author | Recio Huertas, Vanessa | |
dc.contributor.author | Gonzalez-Jimenez, Irene | |
dc.contributor.author | Tarrago Asensio, David | |
dc.date.accessioned | 2023-07-24T11:15:45Z | |
dc.date.available | 2023-07-24T11:15:45Z | |
dc.date.issued | 2023-07-18 | |
dc.identifier.citation | Virol J. 2023 Jul 18;20(1):153. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16306 | |
dc.description.abstract | Resistant CMV infections are challenging complications after SOT and HSCT. Prompt recognition of ARMs is imperative for appropriate therapy. 108 plasma samples from 96 CMV + transplant recipients with suspected resistance were analysed in CNM in a retrospective nationwide study from January 2018 to July 2022 for resistance genotyping. ARMs in UL97 and UL54 were found in 26.87% (18/67) and 10.60% (7/66) of patients, respectively. Patients' ARM distribution in UL97 was as follows: L595S n = 3; L595S/M460I n = 1; L595S/N510S n = 1; L595W n = 1; C603W n = 4; A594V n = 3; A594E n = 1; C607Y n = 1; L397R/T409M/H411L/M460I n = 1; L397I n = 1; H520Q n = 1; four patients showed ARMs in UL54 as well (F412C n = 1; T503I n = 2; P522S n = 1), whereas three patients exhibited ARMs in UL54 only (L501I/T503I/L516R/A834P n = 1; A987G n = 2). L516R in UL54 and L397R/I and H411L in UL97 have been found for the first time in a clinical sample. L595S/W was the most prevalent ARM found to lend resistance to GCV. In UL54 all ARMs lent resistance to GCV and CDV. In addition, A834P, found in one patient, also lent resistance to FOS. CMV load did not differ significantly in patients with or without ARMs, and no differences were found either between patients with ARMs in UL97 or in UL97 and UL54. Despite extensive use of classical antivirals for the treatment of CMV infection after HSCT and SOT, ARMs occurred mainly in viral UL97 kinase, which suggests that CDV and mostly FOS continue to be useful alternatives to nucleoside analogues after genotypic detection of ARMs. | es_ES |
dc.description.sponsorship | This work was supported by a grant from Instituto de Salud Carlos III. AESI2021 PCIII00011-MPY434/2021. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central (BMC) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cytomegalovirus | es_ES |
dc.subject | UL54 gene | es_ES |
dc.subject | UL56 gene | es_ES |
dc.subject | UL97 gene | es_ES |
dc.subject | Transplant patients | es_ES |
dc.subject | Resistance mutations to antivirals | es_ES |
dc.subject | Letermovir | es_ES |
dc.subject | Ganciclovir | es_ES |
dc.subject | Foscarnet | es_ES |
dc.subject | Solid organ transplant | es_ES |
dc.subject | Hematopoietic stem cells transplant | es_ES |
dc.subject.mesh | Cytomegalovirus | es_ES |
dc.subject.mesh | Cytomegalovirus Infections | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Ganciclovir | es_ES |
dc.subject.mesh | Transplant Recipients | es_ES |
dc.subject.mesh | Retrospective Studies | es_ES |
dc.subject.mesh | Phosphotransferases (Alcohol Group Acceptor) | es_ES |
dc.subject.mesh | Antiviral Agents | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.subject.mesh | Drug Resistance, Viral | es_ES |
dc.title | Cytomegalovirus drug resistance mutations in transplant recipients with suspected resistance | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 37464399 | es_ES |
dc.format.volume | 20 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 153 | es_ES |
dc.identifier.doi | 10.1186/s12985-023-02127-7 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | es_ES |
dc.contributor.funder | Conferencia de Rectores de las Universidades Españolas | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1743-422X | es_ES |
dc.identifier.journal | Virology journal | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PCIII00011-MPY434/2021 | es_ES |