Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16287
Título
Torque Teno Virus in Nasopharyngeal Aspirate of Children With Viral Respiratory Infections
Autor(es)
Fecha de publicación
2023-03-01
Cita
Pediatr Infect Dis J. 2023 Mar 1;42(3):184-188.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: Torque teno virus (TTV) is a ubiquitous anellovirus responsible for persistent infections and is considered a marker of immune function. The role of TTV as a facilitator of respiratory infections (RIs) is unknown. Objectives: Our aim was to estimate, in a prospective study, the prevalence of TTV in the nasopharyngeal aspirate (NPA) of hospitalized children <5 years old, with RIs and correlate them with outcomes and immune response. Patients and methods: NPA was taken for testing of 16 respiratory viruses by reverse transcription-polymerase chain reaction (PCR), TTV PCR, and immunologic study. Results: Sixty hospitalized children with an RI were included. A total of 51/60 patients had positive common respiratory viral (CRV) identification. A total of 23/60 (38.3%) children were TTV+ in NPA. TTV+ patients had other CRVs in 100% of cases versus 78.3% in TTV- ( P = 0.029). The TTV+ patients tended to be older, have fever, and to need pediatric intensive care unit admission more often than TTV- patients. Abnormal chest radiograph was more frequent in the TTV+ patients, odds ratios 2.6 (95% CI: 1.3-5.2). The genetic expression of filaggrin (involved in epithelial barrier integrity) was lower in TTV+ patients; however, the levels of filaggrin in the NPA were increased. Conclusions: TTV infection is common in children with RI and could be associated with abnormal imaging in radiograph, greater severity and an alteration in filaggrin gene expression and protein release.
Palabras clave
MESH
DNA Virus Infections | Pneumonia | Respiratory Tract Infections | Torque teno virus | Virus Diseases | Child, Preschool | Humans | DNA, Viral | Filaggrin Proteins | Prospective Studies | Viral Load
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