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dc.contributor.author | Zuriaga, María A | |
dc.contributor.author | Fuster, Jose J. | |
dc.date.accessioned | 2023-07-17T13:38:53Z | |
dc.date.available | 2023-07-17T13:38:53Z | |
dc.date.issued | 2023-02-24 | |
dc.identifier.citation | Circ J. 2023 Feb 24;87(3):394-400 | es_ES |
dc.identifier.issn | 1346-9843 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16280 | |
dc.description.abstract | Accumulating evidence suggests that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, as a substantial risk remains even when these factors are apparently managed well. In this context, clonal hematopoiesis has emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiometabolic conditions. Clonal hematopoiesis typically arises from somatic mutations that confer a competitive advantage to a mutant hematopoietic stem cell, leading to its clonal expansion in the stem cell population and its progeny of blood leukocytes. Human sequencing studies and experiments in mice suggest that clonal hematopoiesis, at least when driven by certain mutations, contributes to accelerated atherosclerosis development. However, the epidemiology, biology and clinical implications of this phenomenon remain incompletely understood. Here, we review the current understanding of the connection between clonal hematopoiesis and atherosclerosis, and highlight knowledge gaps in this area of research. | es_ES |
dc.description.sponsorship | J.J.F. is supported by the Spanish Ministerio de Ciencia e Innovación (grants RYC-2016-20026 and RTI2018-093554-A-I00), the Leducq Foundation (TNE-18CVD04) and the European Research Area Network on Cardiovascular Diseases CHEMICAL (grant AC19/00133 from the Spanish Instituto de Salud Carlos III). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Instituto de Salud Carlos III and the Ministerio de Ciencia e Innovación. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | JAPANESE CIRCULATION SOC | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Cardiovascular Diseases | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Clonal Hematopoiesis | es_ES |
dc.subject.mesh | Hematopoiesis | es_ES |
dc.subject.mesh | Heart Disease Risk Factors | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.title | Emerging Role of Acquired Mutations and Clonal Hematopoiesis in Atherosclerosis - Beyond Conventional Cardiovascular Risk Factors. | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 34433749 | es_ES |
dc.format.volume | 87 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 394 | es_ES |
dc.identifier.doi | 10.1253/circj.CJ-21-0505 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | European Research Area Network on Cardiovascular Diseases | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | es_ES |
dc.contributor.funder | Fondation Leducq | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1347-4820 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1253/circj.CJ-21-0505 | es_ES |
dc.identifier.journal | Circulation journal : official journal of the Japanese Circulation Society | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Hematovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-093554-A-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RYC-2016-20026 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/TNE-18CVD04 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/AC19/00133 | es_ES |