Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16280
Título
Emerging Role of Acquired Mutations and Clonal Hematopoiesis in Atherosclerosis - Beyond Conventional Cardiovascular Risk Factors.
Autor(es)
Zuriaga, María A | Fuster, Jose J. CNIC
Fecha de publicación
2023-02-24
Cita
Circ J. 2023 Feb 24;87(3):394-400
Idioma
Inglés
Tipo de documento
research article
Resumen
Accumulating evidence suggests that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, as a substantial risk remains even when these factors are apparently managed well. In this context, clonal hematopoiesis has emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiometabolic conditions. Clonal hematopoiesis typically arises from somatic mutations that confer a competitive advantage to a mutant hematopoietic stem cell, leading to its clonal expansion in the stem cell population and its progeny of blood leukocytes. Human sequencing studies and experiments in mice suggest that clonal hematopoiesis, at least when driven by certain mutations, contributes to accelerated atherosclerosis development. However, the epidemiology, biology and clinical implications of this phenomenon remain incompletely understood. Here, we review the current understanding of the connection between clonal hematopoiesis and atherosclerosis, and highlight knowledge gaps in this area of research.
MESH
Cardiovascular Diseases | Atherosclerosis | Humans | Animals | Mice | Risk Factors | Clonal Hematopoiesis | Hematopoiesis | Heart Disease Risk Factors | Mutation
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
- Nombre:
- Emerging Role of Acquired_Circ ...
- Tamaño:
- 842.8Kb
- Formato:
- Descripción:
- Artículo